60例青春期多囊卵巢综合征临床资料分析  

Clinical analysis of 60 cases of adolescence polycystic ovarian syndrome

作　　者：方洁[1] 吕淑兰[2] 李斌[1] 

机构地区：[1]湖北医药学院附属东风医院妇产科,湖北十堰442001 [2]西安交通大学医学院第一附属医院妇产科,陕西西安710061

出　　处：《中国妇幼健康研究》2012年第3期341-343,共3页Chinese Journal of Woman and Child Health Research

摘　　要：目的分析青春期多囊卵巢综合征患者的临床和内分泌代谢特征，寻求其早期诊断的依据。方法选择青春期多囊卵巢综合征患者60例，记录一般情况，观察有无多毛、痤疮并评分。抽血测定性激素、糖耐量试验及胰岛素释放试验。经直肠超声测量卵巢体积及卵泡数量。结果100％的青春期多囊卵巢综合征患者有月经紊乱。83．3％有多囊性卵巢（PCO），53．3％有中心性肥胖，45．0％有肥胖，81．5％伴胰岛素抵抗（IR）。与非肥胖者相比，年龄、身体质量指数（BMI）、腰臀比（WHR）、口服葡萄糖后2小时血糖及各时点胰岛素水平差异显著（t=2．38～7．36，均P〈0．05）。68．3％的患者有IR，与非IR相比，年龄、BMI、WHR、睾酮（T）及各时点血糖和胰岛素水平差异显著（t=2．14～5．06，均P〈0．05）。85．0％伴有高雄激素血症，与非高雄者相比，T水平差异显著（t=5．45，P〈0．05）。结论青春期多囊卵巢综合征患者多伴有月经紊乱、PCO、中心性肥胖、IR、高雄激素血症等特征；月经改变以月经稀发为主，继发性闭经次之；肥胖型患者多伴有IR。Objective To analyze the clinical and endocrine metabolism features of adolescence polycystic ovary syndrome （PCOS）, so as to seek basis for early diagnosis. Methods Sixty cases of adolescence PCOS were selected. The general information was recorded, and hirsutism and acne were observed and scored. The blood samples were taken to detect the serum hormone levels, OGrlT and IRT. The volume of ovary and the number of follicles were measured through intrarectal sonography. Results 100% of the adolescence PCOS suffered abnormal menstruation, 83.3% of them had polycystic ovaries （PCO） , 53.3% of them had central obesity, and 45.0% of them had obesity including 81.5% accompanying with IR. Compared with patients with non-obesity, the age, BMI, WHR, OGTF2h and insulin levels at each time point were significantly different （ t = 2.38 - 7.36, all P 〈 0.05 ）. There were 68.3% patients with IR, and their age, BMI, WHR, testosterone, serum glucose and insulin level at each time point were significantly different compared with patients with NIR （ t = 2.14 - 5.06, all P 〈 0.05 ）. There were 85.0% of patients with hyperandrogenism. Compared with non-hyperandrogenism ones, there was significant difference in testosteone level （ t = 5.45, P 〈 0. 05 ）. Conclusion Most of adolescence PCOS accompany with menstrual disorders, PCO, central obesity, IR and hyperandrogenism. Menstrual disorder mainly embodies on oligomenorrhea, followed by secondary amenorrhea. Obese adolescence PCOS has a remarkable trend of suffering IR.

关 键 词：青春期 多囊卵巢综合征 临床特征 内分泌代谢特征 

分 类 号：R711[医药卫生—妇产科学]