高胆红素血症及感染对新生儿红细胞免疫粘附功能的影响  

Influence of Hyperbilirubinemia and Infection on Erythrocyte Immune Function in Neonates

作　　者：宋国英[1] 顾岚[1] 李军[1] 张洁[1] 马岩[1] 刘永琴[1] 

机构地区：[1]南通大学附属吴江市第一人民医院,江苏吴江215200

出　　处：《儿科药学杂志》2012年第7期3-6,共4页Journal of Pediatric Pharmacy

基　　金：2010年度南通大学校级自然科学类科研基金(编号:10Z108);2010年吴江市社会发展计划研究项目(编号:WS201002)

摘　　要：目的:探讨新生儿高胆红素血症和感染因素对红细胞免疫粘附功能的影响。方法:选取2010年1月至2010年12月在南通大学附属吴江市第一人民医院新生儿科住院的135例患儿,血清总胆红素(TBIL)均>220.6μmol/L。按照TBIL浓度和有无感染因素分为两组,同时选择50例正常新生儿作为对照组。分别用花环法测定红细胞C3b受体花环率(E-C3bRR)。结果:新生儿高胆红素血症患儿的E-C3bRR较正常新生儿低,但只有当TBIL>342.0μmol/L时,其E-C3bRR(9.64±2.89)与正常对照组(11.12±3.53)比较差异有统计学意义(t=2.084,P<0.05),并且与TBIL值之间呈负相关(r=-0.363,P<0.05);有感染因素的高胆红素血症患儿的E-C3bRR(9.58±3.02)与正常对照组比较差异有统计学意义(t=2.497,P<0.05);在TBIL浓度相当时,TBIL在220.6～342.0μmol/L时有感染组的E-C3bRR(9.67±3.20)较无感染组(10.93±3.01)降低,两者比较差异有统计学意义(t=1.996,P<0.05);而TBIL>342.0μmol/L时有感染组的E-C3bRR(8.21±2.95)与无感染组(9.78±2.87)比较差异无统计学意义(t=1.622,P>0.05)。结论:血清胆红素明显升高时红细胞免疫粘附功能下降。新生儿感染时,其红细胞免疫粘附功能也下降。合并感染的高胆红素血症红细胞免疫粘附功能更差。Objective： To analyze the influence of hyperbilirubinemia and infection on erythrocyte immune function in neonates. Methods： From January to December, 2010, 135 neonates diagnosed hyperbifirubinemia, with bilirubin levels that exceeded 220. 6 μmol/L, were detected with erythroeyte rossettet test and divided into two groups. Among these neonates, the group 1 whose total bilirubin were between 220.6 i.Lmol/L and 342.0 μmol/L were categorized as two parts, one with infection, the other without infection. Group 2 whose total bilirubin were above 342.0 μmol/L were categorized as two parts, one with infection, the other without infection. 50 healthy neonates were enrolled as the control group. Results： The erythroeyte immune function in neonates with hyperbilirubinemia was lower than that in the control group （ 11.12＋-3.53 ）, hut there was only a significant difference （t = 2. 084, P〈0, 05 ） in group 2 （9.64±2.89）. There was no correlation between the level of bilirubin and the erythrocyte immune function in group 1, but there was positive correlation in group 2 （r=-0. 363, P〈0.05 ）. On the other hand, the erythrocyte immune function in neonates diagnosed hyperbilirubinemia with infection （9.58±3.02） was lower than that in the control group （ t = 2. 497, P〈0. 05 ）. While comparing the bilirubin in group 1, there was a significant difference （t= 1. 996, P〈0.05 ） between the ones with infection （9.67 ±3.20） and the others with out infection （ 10.93±3.01 ）. Comparing the bilirubin in group 2, there was no significant difference （t= 1. 622, P〈0.05 ） between the ones with infection （8.21±2.95 ） and the others without infection （9.78 ±2.87 ）. Conclusions： There was a decrease in e^ythrocyte immune function in neonates with hyperbilirubinemia. The erythrocyte imnmne function of the neonates with infection was decreased too. The erythrocyte immune function in neonates diagnosed with hyperbilirubinemia and infection was much lower than that in the cont

关 键 词：新生儿 高胆红素血症 感染 红细胞 免疫 

分 类 号：R722.1[医药卫生—儿科]