干扰素佐治新生儿轮状病毒肠炎临床疗效观察  

The Effects of Interferon on Neonates with Rotaviral Enteritis

作　　者：朱汉斌 米弘瑛[2] 

机构地区：[1]云南省文山市妇幼保健院,云南文山663000 [2]云南省第一人民医院,云南昆明650032

出　　处：《儿科药学杂志》2012年第7期28-30,共3页Journal of Pediatric Pharmacy

摘　　要：目的:探讨干扰素治疗新生儿轮状病毒性肠炎的疗效。方法:2008年6月至2010年10月住院的新生儿轮状病毒肠炎患儿140例,按随机数表法分为治疗组与对照组各70例。所有病例根据脱水程度、性质给予口服或静脉补液,并口服双歧杆菌乳杆菌嗜热链球菌三联活菌片、蒙脱石散,合理喂养,治疗组在此基础上给予人重组干扰素α-1b注射液10 U/kg皮下注射,1次/d,连用3 d,比较两组有效率、止泻时间、住院时间。结果:显效率治疗组71.4%,对照组41.4%,两组比较差异有统计学意义(χ2=12.81,P<0.01),治疗组平均止泻时间(3.1±1.6)d,平均住院时间(5.6±1.3)d,对照组平均止泻时间(4.2±1.7)d,平均住院时间(8.3±2.4)d,两组比较差异均有统计学意义(u=3.9及8.85,P均<0.01)。结论:干扰素佐治新生儿轮状病毒性肠炎显效快,止泻效果好,无明显不良反应。Objective： To study the effects of interferon on neonates with rotaviral enteritis. Methods： One hundred and forty cases of inpatients from 2008 - 2010 in the Maternal and Child Health Hospital of Wenshan were randomly divided into two groups equally. Based on the conventional therapy, the treatment group was given interferon a-1b. The therapeutic effects, the duration of hospitalization, and the discontinuation of diarrhea between two groups were compared. Results： The efficacious rate was 71.4% in the treatment group,which was higher than that in the control group （41.4 % ） ; the difference was significant between the two groups （ P〈0.01 ）. The length of hospitalization and diarrhea were （5.6±1.3 ）d and （3.1±1.6）d in the treatment group respectively, which were shorter than those in the control group （ 8.3 ±2.4） d and （4.2±1.7 ） d ; the differences between the two groups were significant （ P〈0.01 ）. Conclusions： The Interferon had a fast effect on rotaviral enteritis, and could shorten the diarrhea duration. There was no adverse effect observed.

关 键 词：轮状病毒 肠炎 干扰素 

分 类 号：R722.1[医药卫生—儿科]