重组人生长激素治疗生长激素缺乏性侏儒症  

THE EFFECT OF RECOMBINANT GROWTH HORMONE ON PATIENTS WITH GROWTH HORMONE DEFICIENCY

作　　者：王德芬[1] 陈风生[1] 陈培雄[1] 陈家伦 张达青 郁忠勤 

机构地区：[1]上海第二医科大学附属瑞金医院儿科 [2]上海市内分泌研究所

出　　处：《中华内分泌代谢杂志》1990年第4期198-200,共3页Chinese Journal of Endocrinology and Metabolism

摘　　要：20例原发性垂体性侏儒症、2例单纯性GH缺乏IA型及1例宫内生长停滞的患儿用经典性药物进行激发试验并于夜睡眠中采血测GH,确认有GH缺乏。全部病例用重组hGH治疗。20例用191肽的Genotropin,3例用192肽的Somatonorm,疗程12个月(后一组中1例治疗6个月)。结果一年后身高增长Genotropin组为13.3±1.8cm,Somatonorm组2例各为16.0、16.6cm,1例治疗6个月后为7.9cm。疗程中出现血清T_4下降、轻度肝肿大、一过性血尿者各占47.8％、30.4％、30.4％。Twenty patients (age 9.7±2.6 yrs) with primary pituitary dwarfism, two female sibs(age 8.4 and 11.7 yrs) with isolated growth hormone deficiency type IA (IGHD IA) and one girl (age 5.7 yrs) with intra-uterine growth retardation were investigated for the effect and side effect of recombinant growth hormone Genotropin or Somatonorm. The GH deficiency was defined as serum GH peak below 5 μg/L in two conventional pharmaceutical provocative tests associated with low GH level in sleep. After one year treatment with Genotropin, the twenty patients with primary dwarfism got a growth of 13.3±1.8 cm while with Somatonorm the two sibs with IGHD IA had a height increment of 16.0 cm and 16.6 cm. The girl with intra-uterine growth retardation treated with Somatonorm for six months had a growth of 7.9 cm. During the course of treatment low serum T4, mild liver enlargement and transient microscopic hematuria were found with incidence of 47.8%, 30.4% and 30.4% respectively without serious results.

关 键 词：γ-nGH 侏儒症 GHD 

分 类 号：R584.21[医药卫生—内分泌]