高良姜素对衰老小鼠模型学习记忆的影响  

Galangin Attenuates Cognitive Impairment in Senescent Mice

作　　者：付联群 李秀英 杨成雄[2] 

机构地区：[1]湖北省荆门市第二人民医院药剂科,448000 [2]荆楚理工学院药学院,湖北荆门448000

出　　处：《医药导报》2012年第7期863-866,共4页Herald of Medicine

摘　　要：目的探讨高良姜素对D-半乳糖致衰老小鼠学习记忆能力的改善作用。方法皮下注射D-半乳糖制备小鼠衰老模型。用Morris水迷宫和电跳台法测试小鼠的学习记忆能力,用生物化学方法测定大脑海马超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GPx)、过氧化氢酶(CAT)活性和丙二醛(MDA)含量。结果与正常对照组比较,模型组学习记忆能力减退,大脑海马SOD、GPx、CAT活性降低,MDA含量增高。与模型组比较,高良姜素高、低剂量组均能显著改善衰老小鼠学习记忆能力,提高小鼠海马内SOD、GPx、CAT活性,降低MDA含量。结论高良姜素能显著改善D-半乳糖致衰老小鼠学习记忆能力,提高大脑海马区SOD、GPx、CAT活性,降低MDA的含量,具有较好的抗氧化能力。Objective To investigate the effect of galangin （GL） on cognitive impairment in the senescent mice induced by D-galactose （D-gal）. Methods D-gal was subcutaneously injected to establish a senescent mice model. The Morris water maze test and step-down avoidance one were performed to study the learning and memory abilities of mice. The activities of superoxide dismutase （ SOD ）, glutathione peroxidase （ GPx ）, catalase （ CAT ） and content of malondialdehyde （MDA） in mice hippocampus were detected by biochemical examination. Results The mice treated with D-gal generated significant cognitive deficiency. Administration of GL to D-gal treated mice ameliorated cognitive impairment in the hippocampus. Biochemical examination revealed that GL attenuated the decreased activities of SOD, GPx, CAT and reduced MDA levels in the hippocampus of D-gal-treated mice. Conclusion Galangin possesses anti-oxidative effect by improving the cognitive function, and increasing activities of SOD, GPx, CAT and lowering MDA of the senescent mice induced by D-gal.

关 键 词：高良姜素 D-半乳糖 学习记忆 抗氧化 

分 类 号：R286[医药卫生—中药学] R965[医药卫生—中医学]