利奈唑胺凝胶的制备与质量控制  

Preparation and Quality Control of Linezolid Gel

作　　者：曹高忠[1] 吴继禹[1] 黄爱芳[1] 王志强[1] 

机构地区：[1]温州医学院附属第一医院药剂科,325000

出　　处：《医药导报》2012年第7期910-912,共3页Herald of Medicine

基　　金：温州市科技计划项目(Y20100321)

摘　　要：目的制备利奈唑胺凝胶,并进行质量控制。方法以卡波姆-940、甘油为主要辅料,三乙醇胺调节pH,制备利奈唑胺凝胶,用高效液相色谱法测定其含量,并于25℃留样观察其稳定性。结果所得凝胶质量稳定,含量准确,平均加样回收率为100.91%,RSD=1.93%(n=9)。结论该凝胶制剂处方简单,质量可控,为一种理想的医院制剂。Objective To prepare the linezolid gel and control its quality. Methods Carbomer-940 and glycerol were used as the main ancillary materials for the gel production, triethanolamine was used to regulate pH, the content was determined by HPLC. And the gel was stored at 25℃ for the stability study. Results The quality of the gel was stable and the content was accurate. The average recovery was 100.91% , RSD = 1.93% （ n = 9 ）. Conclusion The preparation is simple and quality is controllable, which is an ideal clinic preparation.

关 键 词：利奈唑胺 凝胶 制备 质量控制 

分 类 号：R978[医药卫生—药品] R944.15[医药卫生—药学]