血清降钙素原和超敏C-反应蛋白在AECOPD的作用  

Clinical significance of serum Procalcitonin and hs C-reactive protein levels on AECOPD

作　　者：李俊[1] 陈弘群[1] 蒋世峰[1] 谢骏[1] 余荣环[2] 曲毅[1] 

机构地区：[1]上海市徐汇区中心医院老年病科,上海200031 [2]上海市徐汇区中心医院呼吸科,上海200031

出　　处：《临床肺科杂志》2012年第8期1368-1370,共3页Journal of Clinical Pulmonary Medicine

摘　　要：目的探讨血清降钙素原(PCT)、超敏C反应蛋白(hs-CRP)水平在AECOPD患者的治疗及预后判断的临床意义。方法选择48例AECOPD及46例COPD稳定期患者,分别测定其PCT、hs-CRP。同时行痰细菌培养。结果 AECOPD组的PCT、hs-CRP水平明显高于COPD稳定期组(P<0.05)。PCT水平与细菌感染有关,AECOPD组中细菌学培养阳性者PCT水平高于阴性者。AECOPD患者中PCT阳性组好转率70.37%,PCT阴性组好转率85.71%。结论在AECOPD患者中,PCT和hs-CRP是较好的诊断指标,尤其在细菌感染的判断上PCT较hs-CRP更有临床价值。PCT可提示病情的严重程度及预后情况。Objective To explore the clinical significance of serum procalcitonin （ PCT）, hs C-reactive protein （hs-CRP） level on diagnosis, treatment and prognosis of acute exacerbation of chronic obstructive pulmonary disease（AECOPD） patients. Methods 48 pa- tients with AECOPD and 46 patients with COPD in stable were selected, and then the PCT, hs-CRP were tested. At the same time, spu- tum bacterial cultures and lung function were made. Results hs-CRP and PCT levels in AECOPD group were significantly higher than those in COPD stable groups with statistical differences （ P 〈 0. 05 ）. PCT levels were positively related with bacterial infections, and in AECOPD group, PCT levels with positive sputum bacterial cultures were significantly higher than those with negative sputum bacterial cul- tures. In AECOPD group, improvement rate of PCT in positive ones was 70. 37%, and 85.71% in negative ones. Conclusion In AE- COPD patients, PCT and hs-CRP are good diagnostic index, especially in bacterial infections. PCT may indicate the severity of the illness and prognosis.

关 键 词：血清降钙素原 超敏C反应蛋白 慢性阻塞性肺病 细菌感染 

分 类 号：R563.9[医药卫生—呼吸系统]