百日咳杆菌感染与成人不明原因慢性咳嗽相关性  

Correlation of Bordetella pertussis infection with cryptogenic chronic cough in adults

作　　者：文芳静[1] 徐志伟 赵景景[1] 肖锦秀[1] 胡克[1] 

机构地区：[1]武汉大学人民医院呼吸科,湖北武汉430060 [2]罗田县万密斋医院,湖北罗田438000

出　　处：《临床肺科杂志》2012年第8期1399-1400,共2页Journal of Clinical Pulmonary Medicine

摘　　要：目的探讨百日咳杆菌感染与成人不明原因慢性咳嗽的相关性。方法采集2010年12月至2011年8月因慢性咳嗽(咳嗽时间>8周,但不符合咳嗽指南中的任何一种原因)就诊于武汉大学人民医院64例患者血清,置于-20℃保存,应用ELISA方法测定患者血清中百日咳毒素的浓度。结果 64例患者中,仅1例为阳性,确诊为百日咳杆菌感染,另63例均呈阴性,百日咳杆菌感染阳性率为1.56%。结论慢性咳嗽患者百日咳感染检出阳性率低。Objective To determin the relationship between eryptogenic chronic cough and Bordetella pertussis infection by de- tect the concentration of pertussis toxin in serum of 64 cases of adult patients with cryptogenic chronic cough. Methods From December 2010 to August 2011, we successfully collected 64 cases who visited Renmin hospital of Wuhan university with the complaint of chronic cough （ All periods exceed 8 weeks, and the aetiology didnt included any causes from the guideline ）. With the method of ELISA, we ex- amine the concentration of pertussis toxin in serum of 64 cases of patients. Results For all 64 cases, only one case was positive. The oth- er 63 cases were negative. The rate of the positive one was 1.56%. Condusion As be different from the report in Europe, we found that the rate of chronic cough resulted from pertussis infection was not very high.

关 键 词：慢性咳嗽 百日咳杆菌 病因学 

分 类 号：R56[医药卫生—呼吸系统]