两种剂量芬太尼复合丙泊酚用于无痛胃镜的麻醉效果  

Two doses fentanyl combined with propofol for painless gastroscopy anesthesia

作　　者：杨云春[1] 李志[2] 刘庆[1] 

机构地区：[1]泸州医学院附属中医院麻醉科,四川泸州646000 [2]泸州医学院附属中医院消化内科,四川泸州646000

出　　处：《西部医学》2012年第7期1327-1328,1330,共3页Medical Journal of West China

摘　　要：目的观察两种不同剂量芬太尼复合丙泊酚用于无痛胃镜检查的麻醉效果。方法将自愿行无痛胃镜检查术的60例患者随机均分为两组:A组:0.5μg/kg芬太尼+0.5%丙泊酚;B组:1.0μg/kg芬太尼+0.5%丙泊酚,观察两组患者血压及血氧饱和度变化;丙泊酚用量;清醒和定向力完全恢复时间;丙泊酚注射痛、术中体动、梦境及术后咽部不适的发生情况。结果两组患者均顺利完成胃镜检查,血压及血氧饱和度无明显变化;A组较B组患者丙泊酚用量更大,但无明显统计学差异(P>0.05);B组患者定向力完全恢复时间较A组延长,但B组患者术中体动发生率低于A组,组间比较有统计学意义(P<0.05);而注射痛、梦境及术后咽部不适两组患者无明显区别(P>0.05)。结论两种剂量的芬太尼联合丙泊酚均能安全用于无痛胃镜检查的患者;1μg/kg芬太尼较0.5μg/kg芬太尼能够减少丙泊酚的用量,减少术中体动的发生比例,但是会延长患者完全定向力的恢复时间;通过加大芬太尼的用量不能减少注射痛、梦境及术后咽部不适的发生。Objective To observe the effect of two different fentanyl doses combined with propofol used in painless gastroscopy anesthetic. Methods 60 patients accepted painless gastroscopy voluntarily were divided into two groups average randomly： group A： 0.5μg/kg fentanyl＋0.5%propofol; group B： lug/kg fentanyl＋0. 5%propofol. Blood pressure,oxygen saturation changing, propofol dosage, awake and directional ability completely recovery time, injection pain, body movement during gastroscopic examination, dreams and postoperative pharyngeal discomfort were observed. Results Two groups patients were successfully accepted gastroscopic examination. The blood pressure and oxygen saturation showed no significant change and the dosage o（ propofol in group B were lower than that in group A, but had no statistically significant. Patient orientation force complete recovery time was longer, but the ratio of patient body movement occurrence during gastroscopy was lower in group B; there was statistically significant between two groups. The propofol injection pain, dreams during gastroscopy and postoperative pharyngeal discomfort in patients were no significant difference between the two groups. Conclusion Two doses of fentanyl combined with propofol used in painless gastroscopy are safe in patients; 1μg/kg fentanyl could reduce propofol dosage, reduce intra-operative body movement occurrence proportion, but prolong the patients orientation force recovery time. Increasing the fentanyl con.sumptJon cannot reduce injection pain, dreams and postoperative pharyngeal discomfort.

关 键 词：芬太尼 丙泊酚 无痛胃镜 

分 类 号：R971.2[医药卫生—药品]