猪成熟脂肪细胞产生的胰岛素抵抗与应激  

Stress and Insulin Resistance on Porcine Matured Adipocytes

作　　者：万庆慧[1] 叶瑞松[1] 赵素梅[1] 高士争[1] 

机构地区：[1]云南农业大学,云南省动物营养与饲料重点实验室,云南昆明650201

出　　处：《云南农业大学学报（自然科学版）》2012年第4期585-589,共5页Journal of Yunnan Agricultural University:Natural Science

基　　金：国家自然科学基金项目(30660132);云南省自然科学基金重点项目(2005C0008Z)

摘　　要：猪脂肪细胞内环境的稳定在脂类代谢过程中起着重要作用。在肥胖等疾病发生过程中,成熟脂肪细胞面临由于能量过剩、炎性反应等造成的内质网应激,导致由于脂肪细胞负荷过重而致内环境稳定的破坏,从而产生胰岛素抵抗。本文就近年来关于猪脂肪细胞应激导致胰岛素抵抗的最新研究进展进行综述,为了解成熟脂肪细胞应激与胰岛素抵抗产生的机制提供参考。Homeostasis adipocytes of pig play an important role in adipocyte metabolism. During the process of obesity and other diseases, factors of energy excess and inflammation lead to stress on endo- plasmic reticulum in mature adipocytes, which leads to the breakdown of homeostasis in adipocytes be- cause of the over metabolism, and finally results in insulin resistance. The new research progress on adipocyte stress leading to insulin resistance was reviewed in this paper, which might provide materials for insight into the mechanism of insulin resistance in obesity of porcine adipocytes.

关 键 词：猪 脂肪细胞 内质网 应激 胰岛素抵抗 

分 类 号：S852.23[农业科学—基础兽医学]