阿托伐他汀影响高血压合并脑血管病患者血压和左室重塑的临床分析  

The Clinical Analysis of Atorvastatin Affect Blood Bressure and Left Ventricular Remodeling of Patients with Hypertension and Cerebrovascular Disease

作　　者：李子彬 刘宁 

机构地区：[1]广东省河源市人民医院心血管内科,广东河源517000

出　　处：《中国医药指南》2012年第18期24-26,共3页Guide of China Medicine

摘　　要：目的探讨阿托伐他汀对高血压合并脑血管病患者血压和左心室重塑的影响。方法选择我院85例高血压合并脑血管病患者随机分为氨氯地平组(10mg/d,A组,n=45)和氨氯地平(10mg/d)加阿托伐他汀组(20mg/d,B组,n=40),连续药物治疗3月。观察给药前后两组患者血压的变化,测定血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)及总三酰甘油(TG)浓度。心脏彩色超声仪测左室后壁厚度(LVPWT)和室间隔厚度(IVST),计算左室重量指数(LVMI)。结果阿托伐他汀给药3个月后,B组患者血清TC、LDL-C及TG浓度均显著降低,而HDL-C明显增高(P<0.05)。药物治疗3个月后,两组患者收缩压和舒张压明显降低,B组血压显著低于A组(P<0.05)。与治疗前比较,两组患者LVMI均明显降低,B组患者LVMI显著低于A组(P<0.05)。结论阿托伐他汀可以显著降低血压和逆转左心室肥厚。阿托伐他汀可通过改善血管内皮功能、降低血压、抑制左心室心肌细胞肥大,来影响高血压合并脑血管病的患者左心室重塑的过程。Ohjeetive To evaluate the efficacy in hypertension with cerebrovascular disease in patients suffering from blood pressure and remoulding of left heart. Methods 85 patients with hypertension with cerebrovascular disease were divided into two group randomly： Therapy group （n=45） was treated with amlodipine 10mg per day. Control group （n=40） was given with amlodipine 10mg per day add atorvastatin 20mg per day, keep 3 months. Evaluate the change of blood pressure and the TC, LDL-C, HDL-C, TG, and the LVPWT, IVST. Results Following up for 3 months, the cardiovascular events of TC, LDL-C and TG were debased,but HDL-C was high. And LVMI were debased （P〈0.05）.Conelusion It＇s more significant clinical value to funtions of improve blood vessel-endodermis use the atorvastatin ,debase blood pressure,and ameliorate the funtiong of the left heart.

关 键 词：阿托伐他汀 高血压 脑血管病 心室重塑 

分 类 号：R544.1[医药卫生—心血管疾病] R743[医药卫生—内科学]