126例妊娠期肝内胆汁淤积症治疗临床分析  

Clinical Analysis on 126 Cases of Intrahepatic Cholestasis of Pregnancy

作　　者：程志霞[1] 郭靖[1] 

机构地区：[1]西安市红十字会医院妇产科,710054

出　　处：《美中国际创伤杂志》2012年第3期4-7,共4页U.S.Chinese International Journal of Traumatology

摘　　要：目的：探讨临床治疗妊娠期肝内胆汁淤积症的疗效。方法：采用回顾性统计分析西安市红十字会医院5年来收治的126例妊娠期肝内胆汁淤积症患者的临床资料，分为研究组（66例）和对照组（60例），采用不同方法治疗，观察其治疗指标变化，并对分娩后情况进行统计。结果：两组患者治疗后瘙痒评分、血清甘胆酸、谷丙转氨酶、谷草转氨酶、总胆红素与直接胆红素的含量平均较治疗前低（研究组：t值分别为3．61，3．45，3．23，3．46，3．25，3．42，均P〈0．01；对照组：t值分别为3．21，2．45，2．74，2．68，2．80，2．77，均P〈0．01）；研究组治疗前后瘙痒评分、血清甘胆酸、谷丙转氨酶、谷草转氨酶、总胆红素与直接胆红素的含量的差值水平较对照组大（f值分别为2．21，2．09，2．03，2．15，2．05，2．11；均P〈0．05）；治疗后，研究组胎儿窘迫、早产及新生儿窒息的发生率较对照组低（妒值分别为4．25，4．58，4．23；P〈0．05）。结论：思美泰与熊去氧胆酸联合用药能提高妊娠期肝内胆汁淤积症的疗效，尤其对于重症患者有更明显的疗效，可以改善新生儿的预后。Objective： To investigate the therapeutic efficacy of intrahepatic cholestasis of pregnancy. Meth- ods： From July 2005 to July 2007, 126 patients with intrahepatic cholestasis of pregnancy were classified as study group （66 cases） and control group （60 cases）, and the data of all cases was retrospectively analyzed. Results： The pruritus score, contents of CG, TBA, ALT, AST, TB and DB were reduced in all patients after treatment （study group： t=3.61, 3.45, 3.23, 3.46, 3.25, 3.42; P〈0.01. control group： t=3.21, 2.45, 2.74, 2.68, 2.80, 2.77; P〈0. 01）, especially the patients in study group, not only the contents of above items were lower than that in control group （t=2.21, 2.09, 2.03, 2.15, 2.05, 2.11; P〈0.05）, but also the incidence rates of fe- tal distress, preterm infant and neonatal asphyxia were lower than that in control group 0（2=4.25, 4.58, 4.23; P〈0.05）. Conclusion： Transmetil combined with ursodeoxycholic acid for treatment of intrahepatic cholestasis of pregnancy can increase the therapeutic effect and improve the prognosis of neonate, especially for the se- vere crises.

关 键 词：思美泰 熊去氧胆酸 地塞米松 妊娠期肝内胆汁淤积症 治疗效果 

分 类 号：R714.255[医药卫生—妇产科学]