早期应用西咪替丁有利于有益菌肠道定植  

Effects of early application of cimetidine to intestinal colonization of beneficial bacteria

作　　者：齐卫斌[1] 沈琼 魏志素[1] 王素敏[1] 安晓燕[1] 樊涛[1] 

机构地区：[1]河北省石家庄市第四医院新生儿科,石家庄050011 [2]武警河北总队医院妇产科

出　　处：《西南国防医药》2012年第7期706-708,共3页Medical Journal of National Defending Forces in Southwest China

基　　金：石家庄市科技局科技支撑计划项目(2011;111461023)

摘　　要：目的探讨早期应用西咪替丁对腹泻患儿有益菌肠道定植的影响。方法选取我院儿科2008年10月～2012年3月126例腹泻病住院患儿资料进行回顾性分析。患儿年龄2个月以内,把患儿按照病程时间分为观察组和对照组,观察组58例病程均<24 h,入院后即给予西咪替丁配合抗生素,常规助消化药治疗。西咪替丁5 mg/(kg.d),口服或静滴均可。对照组68例患儿病程>24 h,给予抗生素和常规助消化药。西咪替丁用法及剂量同观察组。两组患儿同时补液以纠正脱水和酸中毒,调节电解质平衡,调整饮食。观察两组肠道双歧杆菌和乳酸杆菌的定植时间及出院时定植水平。结果观察组双歧杆菌的定植时间为8 d,定植水平为5.97 lg拷贝数/g湿粪;乳酸杆菌为7 d,定植水平为7.00 lg拷贝数/g湿粪,观察组在有益菌定植时间和定植水平方面均优于对照组(P<0.05)。结论患儿肠道有益菌主要是乳酸杆菌和双歧杆菌,患儿腹泻以及使用抗生素后,对肠道的有益菌定植存在着一定的影响。早期使用西咪替丁配合抗生素治疗,可以减轻抗生素对肠道细菌定植的影响,缩短有益菌定植的时间,提高定植的水平,从而保护患儿胃肠道,临床上值得推广。Objective To explore the influence of early application of cimetidine to intestinal colonization of beneficial bacteria in children with diarrhea. Methods A retrospective analysis of clinical data was made in 126 cases of diarrhea that were hospitalized in our department of pediatrics from October 2008 to March 2012. These children aged within two months were divided into observation group and control group according to their course of disease. Fifty eight cases of the observation group with the course of disease shorter than 24 h immediately received cimetidine combined with antibiotics and conventional digestants after admission [cimetidine：5 mg/（kg · d）, oral administration or intravenous infusion]. Sixty eight cases of the control group with the course of disease longer than 24 h received antibiotics, conventional digestants, and cimetidine 24 h after admission. The usage and dosage of cimetidine was the same as that used in the observation group. Fluid replacement was performed among the children in the two groups at the same time in order to correct dehydration and acid poisoning and adjust the electrolyte balance. All of them received dietary therapy. Observation was made in the colonization time of intestinal bifidobacteria and lactobacillus and colonization levels when they discharged. Results In the observation group,the colonization time of bifidobacteria was 8 d and the colonization level was 5.97 lg copy/g wet stool ; the colonization time of lactobacillus was 7 d and the colonization level was 7.00 lg copy/g wet stool, which were better than those indexes in the control group （ P 〈 0.05 ）. Conclusion The intestinal beneficial bacteria in children are mainly bifidobacteria and lactobacillus. The intestinal colonization of these bacteria can be influenced by diarrhea and the use of antibiotics. The early use of cimetidine combined with antibiotic therapy can reduce the effects of antibiotics on the intestinal bacterial colonization, shorten the colonization time, improve the colonization

关 键 词：腹泻 有益菌 肠道定值 西咪替丁 早期应用 儿童 

分 类 号：R723.11[医药卫生—儿科]