银杏叶提取物对ARDS氧化应激及炎症的影响  

The Effects of Ginkgo Biloba Extract on Inflammatory Response and Oxidative Stress in ARDS

作　　者：吴晓琴[1] 黄昭[1] 王思荣[1] 刘继云[1] 

机构地区：[1]广东省广州市第一人民医院重症医学科,510180

出　　处：《中华全科医学》2012年第8期1184-1186,共3页Chinese Journal of General Practice

基　　金：广东省中医药管理局科研基金资助(2007228)

摘　　要：目的观察ARDS患者炎症反应与氧化应激损伤的关系,探讨银杏叶提取物(舒血宁注射液)对ARDS患者的保护作用。方法本研究为前瞻、对照性研究,选择62例2006～2008年广州市第一人民医院ICU住院ARDS患者随机分为对照组(n=32)和治疗组(n=30)。其中治疗组予舒血宁注射液20 ml/d,静脉输注,疗程7 d。治疗前后分别记录和测定两组患者血浆丙二醛(MDA)、还原型谷胱甘肽(GSH)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)水平以及肿瘤坏死因子(TNF-α)、白细胞介素6(IL-6)水平,并进行相关性分析。结果与对照组相比,治疗7 d后治疗组患者血浆MDA水平显著下降,GSH、SOD、GSH-Px明显升高,血清中TNF-α、IL-6水平亦较对照组更低(P<0.05)。此外,血清TNF-α、IL-6浓度与血浆GSH、SOD、GSH-Px水平呈显著负相关,与MDA水平呈明显正相关(P<0.05)。结论银杏叶提取物可有效改善ARDS患者氧化应激损伤及抑制炎性因子释放,有利于ARDS患者的治疗。Objective To investigate the effects of Ginkgo biloba extract（EGb） on inflammatory response and oxidative stress in acute respiratory distress syndrome（ARDS）.Methods Sixty-two patients suffering from ARDS were randomly divided into two groups.The control group was treated regularly and the treatment group was added EGb injection.The plasma maleic dialdehyde（MDA）,glutathione（GSH）,superoxide dismutase（SOD）,glutathione peroxidase（GSH-Px）,tumor necrosis factor-α（TNF-α）,interleukin-6（IL-6） of all patients were monitored and analyzed before and after treatment.Results All patients in treatment group were improved in the indexes of MDA,GSH,SOD,GSH-Px,TNF-α,IL-6 in plasma level when compared with the control one（all P0.05）.It was found that plasma TNF-α,IL-6 were negatively correlated（P0.05） with GSH,GSH-Px,SOD and was positively correlated with MDA（P0.05）.More higher level of TNF-α,IL-6,MDA and lower GSH,GSH-Px,SOD in dead patients（P0.05）.Conclusion EGb can not only inhibit inflammatory mediator but also effective plasma eliminate free radicals in ARDS.It maybe has benefit effect on the treatment of ARDS patients.

关 键 词：银杏叶提取物 急性呼吸窘迫综合征 炎症反应 氧化应激 

分 类 号：R563.8[医药卫生—呼吸系统]