持续皮下输注胰岛素及其类似物对新诊断2型糖尿病疗效比较  

Comparison of Efficacy between Continuous Subcutaneous Insulin Lispro Infusion and Human Regular Insulin Infusion on Newly-Diagnosed Type 2 Diabetes Patients

作　　者：肖天梅[1] 林泽宏[1] 李乐愚[1] 

机构地区：[1]广东省中山市中医院内分泌科,528400

出　　处：《中华全科医学》2012年第8期1238-1240,共3页Chinese Journal of General Practice

摘　　要：目的比较胰岛素泵持续皮下输注速效胰岛素类似物(赖脯胰岛素,优泌乐)和短效人胰岛素(优泌林R)治疗新诊断的2型糖尿病的疗效差异。方法 86例住院需胰岛素治疗的新诊断2型糖尿病患者,随机分为两组:优泌乐组和优泌林R组,胰岛素泵治疗2周,比较两组患者治疗过程中每日3餐前后和睡前血糖、血糖达标时间、胰岛素量、低血糖发生率及胰岛素泵相关的副作用。结果优泌林R组和优泌乐组空腹血糖达标时间分别为(5.77±1.41)d和(3.17±1.36)d(P<0.01),餐后血糖达标时间分别为(8.64±2.39)d及(5.07±1.47)d(P<0.01);2周后3餐前和睡前血糖下降两组间差异无统计学意义(P>0.05);餐后血糖控制情况,优泌乐组优于优泌林R组(P<0.05),优泌乐组胰岛素用量较少,但差异无统计学意义。优泌乐组低血糖发生率低于优泌林R组(P<0.05)。结论胰岛素泵输注优泌乐及优泌林R均能使新诊断的2型糖尿病患者血糖得到良好控制,但优泌乐对餐后血糖控制更理想,血糖达标时所需时间更短,低血糖发生率更低。Objective To compare the efficacy of subcutaneous insulin analogue（insulin Lispro,Humalog） and regular human insulin（Humulin R） infusion by insulin pump in newly-diagnosed type 2 diabetes patients.Methods Eighty-six cases with newly-diagnosed hospitalized diabetes were randomly divided into two groups,Humalog group and Humulin R group,and received continuous insulin infusion for 2 weeks.The level of fasting blood glucose,2 h postprandial blood glucose,the time and the doses of insulin needed for good glycemic control were compared between two groups.The rate of hypoglycemia and pump-related side effects were recorded.Results The time for good fasting glycemic control,good postprandial glycemic control between Humulin R group and Humalog group were（5.77±1.41） d and（3.17±1.36） d（P0.01）,（8.64±2.39） d and（5.07±1.47） d（P0.01）.The level of three meal FBG and glucose before bed between the two groups showed not different after 2w（P0.05）,but postprandial glucose was significant lowered in Humalog group than that in Huminlin R group（P0.05）.The mean dose of insulin of Humalog group was lower but not significantly different.The incidence of hypoglycemia was significantly lower in the Humalog group than in the Humulin R group（P0.05）.Conclusion In newly-diagnosed type 2 diabetic patients,the continuous infusion of insulin Lispro or Humulin R can effectively control blood glucose.The use of Humalog proves more effective with better postprandial glucose level,with a shorter time for good glucose control and with a lower incidence of hypoglycemia compared with Humulin R.

关 键 词：2型糖尿病(新诊断) 胰岛素泵 胰岛素类似物 短效人胰岛素 

分 类 号：R587.1[医药卫生—内分泌]