cTnI与老年UAP患者心肌损伤及心脏事件关系的临床研究  

The Clinical Research of the Relationship between Troponin I and Unstable Angina Elderly Patients' Myocardial Injury and Heart Events

作　　者：赵思义[1] 李伟[1] 杨松[1] 

机构地区：[1]安徽省淮北市人民医院干部内科,235000

出　　处：《中华全科医学》2012年第8期1245-1246,1258,共3页Chinese Journal of General Practice

摘　　要：目的探讨血清肌钙蛋白I(cTnI)与老年不稳定型心绞(UAP)痛患者心肌损伤及心脏事件的关系。方法对35例老年UAP患者、22例稳定性心绞痛(SAP)患者及26例健康对照组分别进行血清cTnI测定,对35例老年UAP患者住院后1个月内心脏事件发生情况进行观察,分析老年UAP患者血清cTnI高低与心脏事件的关系。结果 UAP组的血清cTnI阳性率37.14%高于SAP组的4.54%和健康组的0%,差异有统计学意义(P<0.01),且在UAP患者中BraunwaldⅡ、Ⅲ级组血清cTnI阳性率分别为41.66%和55.55%,明显高于BraunwaldⅠ组(14.28)(P<0.01);住院后1个月内,35例老年UAP患者血清cTnI阳性患者的心脏事件发生率(46.15%)明显高于血清cTnI阴性者的心脏事件发生率(4.54%),P<0.01。结论血清cTnI测定是反映心肌细胞损伤的敏感性和特异性指标,对老年UAP患者心肌损伤程度及近期预后有预测价值。Objective To investigate the relationship between serum cardiac troponin I（cTnI） and unstable angina elderly patients＇ myocardial injury and heart events.Methods The serum cTnl of the 35 unstable angina elderly patients（UAP）,22 stable angina patients（SAP） and 25 healthy men were measured,the occurrence of cardiac events of the 35 unstable angina elderly patients（UAP） in hospital within one month was observed and the relationship between unstable angina elderly patients＇（UAP） serum level and cardiac events was analyzed.Results The serum cTnI-positive rate of the UAP group was 37.14%,which was higher than that of the SAP group（4.54%） and the healthy group（0）.The difference was significant（P0.01）,and among unstable angina elderly patients,Braunwald Ⅱ＇s serum cTnI positive rate was 41.66% and Braunwald Ⅲ＇s serum cTnI positive rate was 55.55%,which was significantly higher than that of Braunwald Ⅰ group（14.28%）,P0.01;Within one month after admission,35 serum cTnI positive unstable angina elderly patients＇ heart event rate（46.15%） is significantly higher than serum cTnI negative unstable angina elderly patients＇ heart event rate（4.54%）（P0.01）.Conclusion The measurement of serum cTnI reflected the sensitivity and specific indicator of myocardial cell injury and predicted the degree of myocardial injury of unstable angina elderly patients（UAP） and recent prognosis.

关 键 词：心肌肌钙蛋白I 不稳定心绞痛 心肌损伤 心脏事件 

分 类 号：R542.2[医药卫生—心血管疾病]