不稳定型心绞痛患者测定UAER、hs-CRP的临床意义  

Clinical Significance of MALB and hs-CRP in Patients with Unstable Angina Pectoris

作　　者：赵有翼[1] 田东霞[1] 

机构地区：[1]北京市平谷区医院检验科,101200

出　　处：《中华全科医学》2012年第8期1295-1296,共2页Chinese Journal of General Practice

摘　　要：目的探讨尿微量白蛋白排泄率(UAER)与超敏C-反应蛋白(hs-CRP)在不稳定型心绞痛诊断中的临床意义。方法将178例临床诊断为不稳定型心绞痛患者分为初发劳力型心绞痛组46例,恶化劳力型心绞痛组50例,自发型心绞痛组54例及梗死后心绞痛组28例;同期正常体检者40例作为对照组,分别应用免疫金标法测定尿微量白蛋白排泄率,免疫比浊法测定超敏C-反应蛋白水平,并进行比较。结果初发型心绞痛组和恶化型心绞痛组的UAER及hs-CRP均有很大程度的增高,二者显著高于对照组(P<0.01);梗死后心绞痛组UAER明显高于对照组(P<0.05),hs-CRP在正常范围;自发型心绞痛组两项测定指标均在正常范围。结论在心绞痛的早期应该注意监测UAER和hs-CRP的变化,以其尽早干预心绞痛的病程进展,对于恶化型劳力型心绞痛需在心肌酶谱和心电图等监测的同时结合UAER和hs-CRP的改变及时采取必要的治疗措施,以阻止或延缓心肌梗死的发生。Objective To study the significance of urinary albumin excretion rate（UAER） and high sensitivity C-reactive protein（hs-CRP） in patients with unstable angina pectoris.Methods All 178 patients with unstable angina pectoris were divided into four groups.Initial onset angina pectoris group consisted of 46 patients,progressive angina pectoris group consisted of 50 patients,spontaneous angina group consisted of 54 patients,and post-infarction angina pectoris group consisted of 28 patients.The level of UAER and hs-CRP were tested and the data were compared to that of 40 healthy controls.Results The levels of UAER and hs-CRP were higher both in initial onset angina pectoris group and progressive angina pectoris group than those of health controls（P0.01）.The UAER in post-infarction angina pectoris group was higher either（P0.05）.Conclusion The level of UAER and hs-CRP in early periods of patients with unstable angina pectoris should be tested so as to get the best curing effect.Combining with myocardial zymogram and electrocardiogram examination,the proper therapy can prevent myocardial infarction.

关 键 词：不稳定型心绞痛 UAER HS-CRP 

分 类 号：R541.42[医药卫生—心血管疾病] R446.112[医药卫生—内科学]