透明质酸对创面胶原代谢的影响  

The effect of extrinsic hyaluronic acid on collagen metabolism in experimental wound healing

作　　者：谭新东[1] 李希军[1] 叶雪玲[1] 

机构地区：[1]武警广东总队医院整形美容中心

出　　处：《中国美容医学》2012年第8期1332-1333,共2页Chinese Journal of Aesthetic Medicine

摘　　要：目的：通过观察外源性透明质酸（HA）对兔耳创面胶原代谢的影响，探讨外源性透明质酸在伤口愈合中的作用。方法：18只日本大耳白兔，建立兔耳创伤愈合模型后，随机分成2％HA治疗组（A组），1％HA治疗组（B组）和生理盐水对照组（C组）。观察创面愈合及瘢痕形成情况，术后第3、7、10、14、18天取标本匀浆后测定羟脯氨酸（HPr）含量，将数据进行统计学处理。结果：A、B两组羟脯氨酸含量明显低于C组（P〈0．01），A、B两组间也有统计学差异（P〈0．05）。A、B两组创面愈合相对c组延迟，形成瘢痕小于C组。结论：外源性HA能够抑制成纤维细胞合成胶原，延迟创面愈合，减少瘢痕形成，其作用有剂量依赖性。Objective By detecting the influence of hydroxyproline on collagen metabolism of wound healing of rabbit ear to investigate the inhibition effect of hyaluronic acid on wound healing. Methods Wound healing model were made on the ears of 18 rabbits. They were randomly divided into 2%HA treated-group （groupA）, 1%HA treated-group （groupB） and normal saline treated-group （groupC）. The wound healing time and scare formation were observed and recorded. The wound area skin was obtained at different days after operation. Tissue hydroxyproline was detected. Data was analyzed statisticaly. Results The hydroxyproline content in group A and B were lower than group C （P〈0.01）. The difference between group A and B was also prominent （P〈0.05）. The wound healing time of group A and B were later than group C, the scars also smaller than group C. Conclusion Hyaluronic acid can inhibit the collagen synthesis, delay the wound healing, reduce the scar formation. The dependence relationship between effect and dosage is notable.

关 键 词：透明质酸 创面愈合 羟脯氨酸 

分 类 号：Q591.2[生物学—生物化学]