308nm准分子激光联合他克莫司软膏治疗白癜风随机对照研究  

Randomized controlled trial of 308nm excimer laser combined with topical tacrolimus ointment in the treatment of vitiligo

作　　者：王筱雯[1] 李强[1] 李凯[1] 刘玲[1] 坚哲[1] 汤玲珍[1] 黄也[1] 宋璞[1] 张雅珺[1] 韦超[1] 周福波[1] 石琼[1] 李舒丽[1] 张楠[1] 李春英[1] 高天文[1] 

机构地区：[1]第四军医大学西京医院全军皮肤病研究所

出　　处：《中国美容医学》2012年第8期1358-1360,共3页Chinese Journal of Aesthetic Medicine

基　　金：国家自然科学基金(30972642,81172749,81130032)

摘　　要：目的：探讨308nm准分子激光联合他克莫司软膏治疗白癜风的临床疗效和安全性。方法：采用随机自身对照方法，将137例白癜风患者双侧对称部位皮损随机分为两组，治疗组采用308nm准分子激光联合他克莫司软膏治疗；对照组单用308nm准分子激光治疗。治疗2个月后评价疗效。结果：总有效率治疗组为97．8％（134／137），对照组为84．7％（116／137）；显效率治疗组为47．7％（65／137），对照组为24．8％（34／137）。两组间的总有效率和显效率差异均具有统计学意义（P〈0．05）。结论：308nm准分子激光联合他克莫司软膏治疗白癜风疗效好，不良反应少。Objectives To observe and evaluate the efficacy and laser and topical tacrolimus ointment in the treatment of vitiligo. safety of the combined therapy using 308rim excimer Methods 137 vitiligo patients were recruited in the randomized self-controlled study. Lesions in the symmetrical regio were randomly divided into two groups including the combined treatment group and the control group using only 308nm excimer laser. The clinical therapeutic efficacy was analyzed after using the therapy for two months. Resluts 97.8% of the patients （134/137） in the treatment group as well as 84.7% of the patients （116/137） in the control group were repigmented. Additionally, there were 47.7% of the patients （65/137） in the treatment group and 24.8% of the patients （34/137） in the control group whose repigmentation rate was no less than 50%. Significant differences of the repigmentation rate were observed between the two groups （P〈0.05）. Conclusions The combined therapy of 308nm excimer laser with topical tacrolimus ointment is more effective in the treatment of vitiligo with little adverse reactions.

关 键 词：308NM准分子激光 他克莫司软膏 白癜风 

分 类 号：R758.41[医药卫生—皮肤病学与性病学]