慢性疲劳综合征与XMRV关系之争  

Conflicts in association between chronic fatigue syndrome and xenotropic murine leukemia virus-related virus

作　　者：张拥军[1,2] 

机构地区：[1]福建省人兽共患病研究重点实验室福建省疾病预防控制中心,福州350001 [2]福建医科大学公共卫生学院教学基地 [3]福州350001

出　　处：《中国人兽共患病学报》2012年第7期735-738,共4页Chinese Journal of Zoonoses

基　　金：福建省自然科学基金项目(2011J01126)~~

摘　　要：慢性疲劳综合征(CFS)的病原学一直没有明确的结论。2009年美国一家实验室在《科学》杂志发表论文,宣称在CFS患者样品中检测到一种逆转录病毒XMRV。而随后对其它CFS人群相关样品的一系列调查却不支持该结论。经过全球科学家近两年的重新调查,证明该实验室所用细胞系、PCR试剂可能存在污染,2011年底《科学》杂志撤销了这篇论文。这次事件说明,病原生物学研究中要警惕实验室污染,需要严谨地提出新的病原体与疾病的关系。The etiology of chronic fatigue syndrome （CFS） remains unknown. It was reported in a 2009 SCIENCE paper by researchers from Nevada, US, that sequences of a novel retrovirus, xenotropic murine leukemia virus-related virus （XMRV）, were detected in high frequency from specimens of CFS patients. However, this observation was challenged by con- troversial findings obtained from many laboratories in other CFS populations worldwide. Intensive investigations demonstrated multiple sources of laboratory contamination, from cell lines to commercial PCR reagents, contributed to these false positive re- suits. Therefore, SCIENCE fully retracted that paper at the end of 2011. This event highlighted possible laboratory contami nation in the pathobiology field, while scientists should be more cautious in proposing etiological roles of any emerging patho- gens.

关 键 词：慢性疲劳综合征 异嗜性鼠白血病病毒相关病毒 病原生物学 

分 类 号：R373.9[医药卫生—病原生物学]