不同复方药剂对沙林染毒兔的救治研究  

Therapeutic effect of different drug compounds on Sarin(GB) intoxication rabbits

作　　者：李丽琴[1] 张瑞华[1] 石童[1] 鹿晓晶[1] 徐建富[1] 

机构地区：[1]防化研究院,北京102205

出　　处：《军事医学》2012年第6期420-423,共4页Military Medical Sciences

摘　　要：目的探讨不同抗胆碱能化合物联合氯解磷定对沙林染毒兔的救治效果,为药物联合应用的合理救治方案提供依据。方法通过测定几种抗胆碱能化合物与氯解磷定单独或者联合应用对沙林染毒兔的防护比率,并结合动物救治过程中体内乙酰胆碱酯酶(AChE)和丁酰胆碱酯酶(BChE)活性恢复情况,确定疗效较好的可与氯解磷定联合应用的抗胆碱能化合物。结果阿托品、盐酸戊乙奎醚、氯解磷定单独应用时对中毒兔的防护比率均小于1.20;不同种类抗胆碱能药物与氯解磷定联合应用时,3种盐酸戊乙奎醚联合其他药物的防护比率均较2种阿托品联合其他药物的防护比率高,前者对动物的防护比率为3.68～3.80,后者对动物的防护比率为2.30～2.56。采用盐酸戊乙奎醚和贝那替秦与氯解磷定联合应用对沙林重度染毒兔的疗效为77.8%。结论采用盐酸戊乙奎醚和贝那替秦与氯解磷定联合应用对沙林染毒兔有较好的救治效果。Objective To explore the effect of different drug compounds containing anticholinergic agents and pralidoxime chloride（PAM-Cl） on sarin（GB）-intoxicated rabbits.Methods The protection ratios of GB intoxicated rabbits by anticholinergic drugs and PAM-Cl alone or in combination was studied.The AChE and BChE activities of intoxicated rabbits were determined in the course of rabbit remedy.The anticholinergic compounds with the best therapeutic effect were identified.Results The protection ratio of anticholinergic agents,such as atropine,penehyclidine hydrochloride or PAM-Cl alone,was less than 1.20.The protection ratios of three types of compounds containing anticholinergic agents and penehyclidine hydrochloride was higher than that of the other two kinds of compounds containing atropine：3.68-3.80 compared to 2.30-2.56.The survival rate of serious GB intoxicated rabbits was 77.8% after being treated with the best compounds.Conclusions The drug compounds containing penehyclidine hydrochloride,benactyzine and PAM-Cl may have a good therapeutic effect on GB intoxicated rabbits.

关 键 词：抗胆碱能药物 沙林 阿托品 药物疗法 联合 救治 乙酰胆碱酯酶 丁酰胆碱酯酶 活性 

分 类 号：R595.4[医药卫生—内科学]