浙江舟山群岛居民甲状腺功能亢进症患病情况调查  

Investigation of the Prevalence of Hyperthyroidism in Zhoushan Archipelago

作　　者：赵臣银[1] 竺王玉[1] 刘晓光[1] 周世权[1] 王晔恺[1] 胡晓斐[1] 郑笑娟[1] 袁惠萍[1] 张永奎[1] 

机构地区：[1]浙江省舟山市人民医院,316000

出　　处：《医学研究杂志》2012年第7期37-39,共3页Journal of Medical Research

基　　金：国家星火计划项目(2008GA700174);浙江省科技厅面上项目(2008C33043)

摘　　要：目的调查浙江舟山群岛各地区甲状腺功能亢进症(简称甲亢)患病情况及相关致病因素。方法对舟山海岛地区1389名城镇居民、502名农民、737名盐民、362名渔民及294名普陀山僧侣进行流行病学问卷调查、血清促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、甲状腺过氧化物酶抗体(TPOAb)和尿碘测定。8～10岁儿童仅行尿碘检测。结果舟山海岛地区城镇居民、农民、盐民、渔民及普陀山僧侣的尿碘中位数(MUI)分别为320.7μg/L、188.9μg/L、122.2μg/L、193.6μg/L and 271.7μg/L,临床甲亢和亚临床甲亢的患病率分别为0.50%、0.40%、0.41%、0.55%、0.34%和0.79%、0.80%、0.68%、0.83%、0.68%,女性较男性更易患甲亢,TPOAb阳性者患甲亢危险性较高(P<0.05)。结论舟山海岛地区碘营养充足,需警惕自身免疫性甲亢的发生。Objective To investigate the prevalence of hyperthyroidism and explore its assosiated risk factors in various regions in Zhoushan archipelago. Methods All the residents in Zhoushan archipelago,including 1389 urban residents,737 salt -maked, 362 fish- ers and 294 buddhist in Putuo Mountain, were surveyed by questionnaire and their serum thyroid stimulating hormone （TSH） , free triiodo- thyronine 3 （ FT3 ） , free thyroxine （ FT4 ） , thyroid peroxidase antibody （TPOAb） and urinary iodine were detected. Results The median levels of urinary iodine of urban residents, famers, salt - maked, fishers, buddhist were 320.7 μg/L, 188.9 μg/L, 122.2 p,g/L, 193.6μg/L and 271.7 μg/L respectively, while the prevalence rates of hyperthyroidism and subclinical hyperthyroidism were 0.50% ,0.40% ,0.41% , 0.55% ,0.34% and 0.79% ,0.80% ,0.68% ,0.83% ,0.68% ,respectively; Female and the TPOAB - positive had the higher risk of hy- perthyroidism （P 〈 0. 05 ）. Conclusion The residents of ZhouShan Archipelago had an adequate iodine in - take, so that they should be aware of higher incidence of autoimmune hyperthyroidismand.

关 键 词：碘 甲状腺功能亢进 海岛 流行病学 

分 类 号：R581.1[医药卫生—内分泌]