组织工程支架材料——交联透明质酸置入角膜生物相容性研究  

Biocompatibility of Cross-linked Hyaluronic Acid Implanted in Cornea as Scaffold Materials for Corneal Tissue Engineering

作　　者：郝念[1] 胡勇平[1] 张惠成[1] 刘小玲[2] 董映[1] 

机构地区：[1]杭州市第一人民医院眼科,310006 [2]杭州师范大学,310036

出　　处：《医学研究杂志》2012年第7期83-85,共3页Journal of Medical Research

基　　金：浙江省科技计划基金资助项目(2008c23058)

摘　　要：目的探讨交联透明质酸材料对兔角膜组织的生物学反应的影响,评价其作为角膜组织工程支架材料的可行性。方法将交联透明质酸材料置入兔角膜基质层间内3个月,观察置入材料在角膜内生物学反应。结果观察期内交联透明质酸材料与兔角膜基质愈合良好,角膜组织学观察未见有淋巴等炎症细胞浸润。结论交联透明质酸材料置入兔角膜后无明显炎症反应,其生物相容性良好,是一种理想的角膜组织工程支架材料。Objective To compare the biological response of cross - linked hyaluronic acid as scaffold materials for corneal tissue engineering. Methods Discs with 5.0mm diameter of cross - linked hyaluronic acid were inserted into rabbits＇ intcrlamcllar stromal pockets and followed up for a period of 3 month. Results After 3 months, cross - linked hyaluronic acid scaffold materials were partly al- tered. Histological study demonstrated that cross - linked hyaluronic acid scaffold materials fused with rabbits＇ corneal stroma without lym- phocyte infiltrating. Conclusion Embedded cross- linked hyaluronic acid dose not increase inflammatory reaction mostly, and the bio- compatibility of these materials is good.

关 键 词：角膜组织工程 生物相容性 透明质酸 支架材料 

分 类 号：R332.2[医药卫生—人体生理学]