血液透析治疗在慢性心肾综合征的应用和疗效分析  

Clinical Analysis of Hemodialysis Treatment for Cardiorenal Syndrome

作　　者：姚于泓[1] 陈有仁[1] 许平辉[1] 

机构地区：[1]汕头大学医学院第二附属医院血液透析室,515041

出　　处：《医学研究杂志》2012年第7期89-91,共3页Journal of Medical Research

基　　金：汕头市重点科技计划基金资助项目(201063)

摘　　要：目的探讨血液透析治疗(HD)在心肾综合征(CRS)治疗中的实际价值。方法选择2009年12月～2011年9月在笔者医院住院的终末期心力衰竭合并肾功能损害患者共计30例,按照肾小球滤过率(GFR)下降程度分为轻、中度和重度、衰竭两组,分别收集患者治疗前后症状、体征、生化检查、X线胸片、心脏彩超检查等临床资料并进行比较。结果两组患者在HD治疗后症状和体征均不同程度改善,t分别为3.02(P<0.05),7.09(P<0.01),两组间症状和体征改善程度无明显差别,t=0.099(P>0.05);两组治疗后GFR出现明显增加,t分别为6.301、4.680(P<0.01),尿蛋白排泄明显减少,t分别为5.470,4.165(P<0.01)。结论 HD在CRS治疗过程中能减轻心力衰竭症状、体征,改善肾功能,可作为CRS早期治疗方式之一。Objective To explore the role of hemodialysis treatment for cardiorenal syndrome. Methods Totally 30 patients suf- fered from the end state of heart failure and the renal injury in our hospital from December 2009 to September 2011 were selected. Accord- ing to the GFR level,30 patients were divided into two group：l 8 patients＇ GFR ranged from 30ml/min to 90ml/min, and other 12 patients＇ experiened severy decrease in GFR（ GFR 〈 30ml/min） . We compared all the clinical rcsourses （ signs, chemical examine, chest X - ray, echocardiogram） between two groups pre- and post- hemodialysis. Results The signs were improved after hemodialysis separately in two groups[ tI = 3.02（P 〈 O. 05） ,t2 = 7.09 （P 〈 0.01 ） 1- No difference between two groups for the improvement of signs was found （t = 0. 099, P 〉 0.05 ）. After themodialysis, GFR was obviously raised [ t1 = 6. 301 （ P 〈 0.01 ） , t2 = 4.68 （ P 〈 0.01 ） ] , urinable protein decrease clearly[ t1 = 5.47 P 〈 0. 01 ） , t2 = 4. 165 （ P 〈 0.01 ） ] in two groups. Conclusion HD treatment for cardiorenal syndrome can lighten the signs of heart failure,improve renal function. It may be one of treatment for CRS on early time.

关 键 词：血液透析 心肾综合征 肾小球滤过率 心力衰竭体征 尿蛋白 

分 类 号：R692.5[医药卫生—泌尿科学]