黄酮甙对大鼠胃泌素及胃运动的影响  

A study on the effects of flavonoids glucoside on serum gastrin level and gastric motility of rats

作　　者：张茂[1] 李瑞[1] 吴小玫[1] 丁东婧[1] 王刚[2] 刘彬[2] 

机构地区：[1]重庆医科大学附属儿童医院中医科,400014 [2]重庆医科大学附属儿童医院药剂科,400014

出　　处：《重庆医学》2012年第19期1962-1963,共2页Chongqing medicine

摘　　要：目的研究黄酮甙对胃泌素及胃运动的影响。方法实验组(A组)从枳实中提取黄酮甙对大鼠灌胃,B组用红霉素对大鼠灌胃,C组用生理盐水对大鼠灌胃。检测各组大鼠血浆中胃泌素含量,用生理记录仪记录黄酮甙对胃排空和胃运动的影响。结果 A、B组与C组比较,大鼠血浆中胃泌素含量均明显增高(P<0.05);A组胃泌素含量明显高于B组(P<0.05)。A、B组胃肌电慢波频率与C组比较,差异有统计学意义(P<0.01);A组与B组比较,差异也有统计学意义(P<0.05)。结论黄酮甙通过促进胃泌素的分泌提高胃的收缩力,增强胃排空来调节胃运动。Objective To study the influences of gastrin（the active ingredient of frutus） on stomach movement function and secretion by flavonoids glucoside. Methods The rats of group A were irrigated stomach with flavonoids glucoside extracted from frutus,the rats of group B with erythromycin,the rats of group C with saline water. Extracted serum from all these rats,and detected gastrin,studied the influences of stomach on movement and emptying function by physiological recorder. Results The levels of gas trin in group A and B were significantly higher than group C;The level of gastrin in group A was significantly higher than group B （P〈0.05）. The changes of stomach muscle electricity were significiant differences in group A and B comparing with group C（P〈 0.01） ; There was a remarkable difference in stomach muscle electricity between group A and B（P〈0.05）. Conclusion Flavonoids glucoside of frutus can improve the stomach contraction and enhance gastric emptying by enhancing the secretion of gastrin.

关 键 词：黄酮类 胃泌素类 大鼠 

分 类 号：R285.5[医药卫生—中药学]