EB病毒感染与恶性血液病相关性研究  

Association between Epstein-Barr virus infection and malignant hematologic diseases

作　　者：桂瑞瑞[1,2,3,4] 周健[1,2,3] 张艳莉[1,2,3] 房佰俊[1,2,3] 符粤文[1,2,3] 魏旭东[1,2,3] 宋永平[1,2,3] 

机构地区：[1]郑州大学附属肿瘤医院血液科 [2]河南省肿瘤医院血液科 [3]河南省血液病研究所,郑州市450052 [4]郑州大学第一附属医院血液科

出　　处：《中华实验和临床感染病杂志（电子版）》2012年第3期16-18,共3页Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition)

基　　金：国家自然科学基金(No.81070398)

摘　　要：目的探讨EB病毒(EBV)感染与恶性血液病的关系及治疗情况。方法应用荧光定量PCR(FQ-PCR)方法检测37例淋巴瘤患者,39例白血病患者(其中髓系白血病18例,淋巴细胞白血病21例),46例多发性骨髓瘤患者和27例非恶性血液病患者(对照组)外周血的EBV DNA定量,并进行统计学分析及抗病毒治疗。结果淋巴瘤组、髓系白血病组、淋巴细胞白血病组、多发性骨髓瘤组和对照组EBV DNA阳性率分别为32.4%(12/37)、22.2%(4/18)、38.1%(8/21)、43.5%(20/46)和11.1%(3/27)。淋巴瘤组、淋巴细胞白血病组、多发性骨髓瘤组与对照组EBV DNA阳性率比较差异均有统计学意义(P<0.05)。髓系白血病组与对照组EBV DNA阳性率比较差异无统计学意义(P>0.05)。抗病毒治疗后,EBV DNA转阴患者35例,持续阳性者12例。结论 EBV感染与恶性淋巴系统疾病关系密切,与髓系白血病无显著相关性,阿糖腺苷针剂和(或)阿昔洛韦针剂治疗针对其有效。Objective To explore the relationship and therapeutic effect between EBV infection and malignant hematologic diseases. Methods EBV-DNA in peripheral blood was detected by fluorescent quantitative polymerase chain reaction （FQ-PCR） in 37 cases of patients with lymphoma, 39 cases with leukemia, 46 cases with multiple myeloma and 27 cases with non-malignant hematologic disease （control group）. Then the efficacy was observed and analyzed statistically. Results The positive rate of EBV DNA in lymphoma group, myeloid leukemia group, lymph-ocyte leukemia group, multiple myeloma group and control group were 32.4% （12/37） ,22. 2% （4/18）, 38. 1% （8/21） ,43.5% （20/46） and 11. 1% （3/27）, respectively. Compared with the control group, the difference were statistically significant in the positive rate of EBV DNA of lymphoma group, lymphocytic group and multiple myeloma group （ P 〈 0.05 ）, but there was no significant difference between control group and myeloid leukemia group（ P 〉 0.05 ）. After anti-virus therapy, EBV DNA in 35 cases were negative and 12 cases were positive. Conclusions EBV is closely associated with malignant lymphocyte system diseases, but not associated with myeloid leukemia. The adenine arabinoside and/or acyclovir in anti-virus therapy is effective.

关 键 词：EB病毒 淋巴瘤 白血病 多发性骨髓瘤 

分 类 号：R55[医药卫生—血液循环系统疾病]