甲型H1N1流感患者T淋巴细胞亚群动态变化分析  

Dynamic changes of T cell subgroup in patients with influenza A(H1N1) infection

作　　者：李亚玲[1] 刘大凤[1] 温贤敏[1] 刘纯芳[1] 曹燕[1] 

机构地区：[1]成都市传染病医院,成都市610061

出　　处：《中华实验和临床感染病杂志（电子版）》2012年第3期63-65,72,共4页Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition)

基　　金：四川省2010年第一批科技支撑计划项目(No.2010SZ0014);四川省中医药管理局中医药科技专项课题(No.2009A02)

摘　　要：目的探讨甲型H1N1流感不同临床类型及不同阶段T淋巴细胞亚群变化特征。方法回顾性分析2009年本院确诊的271例甲型H1N1流感患者的临床类型、疾病不同阶段T淋巴细胞亚群变化情况。结果甲型H1N1流感患者CD3+T、CD4+T和CD8+T淋巴细胞计数在发病期均明显下降,且其下降程度随疾病严重程度增加而增加;CD4+%及CD4+/CD8+亦随疾病严重程度加重有降低趋势,CD8+%随疾病严重程度加重有增加趋势;甲型H1N1流感轻症患者CD3+T、CD4+T和CD8+T淋巴细胞计数在确诊后第3天恢复正常,甲型H1N1流感重症、危重症患者CD3+T、CD4+T和CD8+T淋巴细胞计数在确诊后第3天开始有下降趋势,在病毒转阴时恢复至基础水平,但未恢复至正常;CD4+%、CD8+%和CD4+/CD8+无明显动态变化。结论甲型H1N1流感患者T淋巴细胞计数在疾病不同时期呈现动态变化,且其变化因疾病严重程度不同而不同。Objective To analyze the dynamic changes of T call subgroup in different clinical stages and different clinical types in severe influenza A （H1N1） cases confirmed in our hospital. Methods Dynamie changes of T cell subgroup in different clinical stages and different clinical types of 271 influenza A （H1N1） admitted in our hospital in 2009 were analyzed, retrospectively. Results In patients with acute phas~, the amount of CD3 ＋ T, CD4＋ T and CD8 ＋ T cell decreased significantly, respectively. The decreased degree increased with disease severity increasing. CD4 ＋% and CD4 ＋/CD8 ＋ also decreased with disease worsening, while CD8＋~ % increased with disease worsening. In mild case, the amount of CD3 ＋ T, CD4 ＋ T and CD8＋ T cell turned to normal after three days. But in severe and critical patients, it began to decrease three days later, and turned to abnormal but basal level at the time of virus negative. Dynamic changes of CD4 ＋ % , CD8＋ % and CD4＋/CD8＋ were not significant. Conclusions Dynamic change of T cell subgroup are different with different clinical stages and different clinical types in severe influenza A （H1N1） case.

关 键 词：甲型H1N1流感 T淋巴细胞亚群 动态变化 

分 类 号：R511.7[医药卫生—内科学]