湖南汉族人群MICB等位基因多态性与白血病的相关性研究  

A Study on the Correlation between MICB Alleles Polymorphism and Leukemia in Hunan Han Population

作　　者：罗奇志[1] 龚拯[1] 余平[1] 林琳[1] 王芙艳[1] 霍治[1] 

机构地区：[1]中南大学基础医学院免疫学系,湖南长沙410078

出　　处：《激光生物学报》2012年第3期224-232,共9页Acta Laser Biology Sinica

基　　金：湖南省自然科学基金(08jj3060)

摘　　要：目的:研究湖南汉族人群MICB等位基因的多态性与白血病的相关性。方法:MICB等位基因分型用PCR-SSP和PCR-SBT的方法。结果:白血病患者中有13种MICB等位基因被检测出,其中MICB*005:02/010基因频率较对照组显著偏低(OR=0.416,P<0.05)。不同类别白血病之间MICB等位基因多态性没有显著差异。结论:MICB*005:02/010等位基因可能与白血病的保护相关。Objective ： To study on the polymorphism of M1CB and its correlation with leukemia in Hunan Han population. Methods：PCR-SSP and PCR-SBT were used to analyze the gene polymorphism of MICB. Results：13 allelic genes were found in patients of leukemia, and the frequency of MICB ＊ 005：02/010 was significantly lower than that of control group （OR = 0. 416, P 〈 0.05 ）. There was no significant difference of MICB gene frequency between different types of leukemia. Conclusions：MICB ＊ 005：02/010 allelic gene polymorphisms may be associated with leukemia protection.

关 键 词：MICB基因 基因多态性 白血病 

分 类 号：R392.1[医药卫生—免疫学]