基于谱域相干的细胞动态检测技术  

Cell Dynamic Detection Based on Spectral-domain Optical Coherence Tomography

作　　者：崇博[1] 朱永凯[1] 

机构地区：[1]南京航空航天大学自动化学院,江苏南京210016

出　　处：《激光生物学报》2012年第3期273-278,共6页Acta Laser Biology Sinica

基　　金：航空科学基金(2011ZD52049);南京航空航天大学基本科研业务费专项科研项目(NS2011017);南京航空航天大学研究生创新基地(实验室)开放基金(201002011)

摘　　要：将谱域光学相干层析技术(Spectral-domain Optical Coherence Tomography,SD-OCT)应用于细胞膜厚的动态检测,引入了光谱干涉测量方法,通过对干涉光谱信号进行离散傅里叶变换得到表示物体深度位置信息的光程差信号。搭建了一套SD-OCT测量系统并设计了专门用于细胞检测的样品平台,检测精度达到μm量级,信噪比达70 db,是一种快速、实时、非接触的细胞分子膜厚动态检测技术。Spectral-domain Optical Coherence Tomography is used to detect the thickness of cell model dynamically. The method of Spectral Interferometry is introduced to process the signal by Discrete Fourier Transform. SD-OCT meas- urement system is set up and a platform is designed specifically for cell detection. Experiments show that the system is a- ble to detect the thickness of cell and molecule quickly dynamically and non-contact. The accuracy of this system is several microns.

关 键 词：谱域光学相干层析技术 细胞分子 干涉光谱 离散傅里叶变换 动态检测 

分 类 号：TH744[机械工程—光学工程] O439[机械工程—仪器科学与技术]