小于胎龄儿的高危因素Logistic回归分析  

Logistic regression analysis about the risk factors of small for gestational age

作　　者：李盛强[1] 周守方[1] 袁贵龙[1] 

机构地区：[1]广州中医药大学附属南海妇产儿童医院新生儿科,广东佛山528200

出　　处：《中国妇幼保健》2012年第20期3126-3128,共3页Maternal and Child Health Care of China

摘　　要：目的:探讨小于胎龄儿的主要危险因素,为制定适宜的预防和干预措施提供科学依据。方法:选择2008～2009年单胎活产小于胎龄儿59例作为病例组,采用完全随机抽样方法选取出生体重在10%～90%分位的适于胎龄儿65例作为对照组。比较两组的胎龄、生长激素、胰岛素抵抗、镁离子浓度、孕妇体质指数、疾病情况、孕妇年龄、父亲吸烟、酗酒等,对上述资料先进行单因素分析,在此基础上选择有统计学差异的变量进行多因素非条件Logistic回归分析。结果:小于胎龄儿在生长激素、镁离子浓度、妊娠年龄方面明显低于适于胎龄儿,差异有统计学意义(P<0.05)。小于胎龄儿在胰岛素抵抗水平、妊娠高血压、父亲酗酒率、父亲吸烟率方面明显高于适于胎龄儿,差异有统计学意义(P<0.05)。Logistic回归分析表明,镁离子浓度、妊娠年龄、父亲酗酒可作为小于胎龄儿的独立相关因素。结论:镁离子可能是胎儿生长发育的重要调控因子;孕妇的妊娠年龄小和父亲的酗酒会使小于胎龄儿产生的几率大大增加。Objective：To study the main risk factors of small for gestational age（SGA） infant and to provide scientific basis for appropriate prevention and intervention measure.Methods：The SGA group included 59 singleton alive SGA delivered in our hospital during January 2008 to December 2009,65 cases were randomly selected by birth weight of 10% to 90% of its spaces appropriate for AGA and taken as a control group.Two groups were compared in gestation age,growth hormone,insulin resistance,density of magnesium ion,pregnant women＇s physique index,disease situation,pregnant women＇s age,father smoke,get drunk,etc.Simple logistic regression analysis was performed for all the risk factors,and variables with statistical significance were chosen for multivariate and unconditioned logistic regression analysis.Results：The levels of growth hormone,density of magnesium ion,pregnant women＇s age in the SGA group were significantly lower than those of the control group（P〈0.05）,while the level of insulin resistance,ratio of coronary artery disease,father alcoholism rate,the father smoking rate was significantly higher than appropriate for gestational age infant（P〈0.05 or P〈0.01）.Logistic analysis showed that the magnesium ion concentration,gestational age,father＇s alcoholism can be an independent factor for SGA children.Conclusion：Magnesium ion may be important regulating factor of fetal growth and development,and pregnant women gestational age and father＇s alcoholism can significantly increase the chances of SGA children.

关 键 词：小于胎龄儿 相关因素 调控因子 

分 类 号：R714.5[医药卫生—妇产科学]