感染血吸虫对1型糖尿病保护性机制研究进展  

The Protective Mechanism of Schistosomes to Type 1 Diabetes

作　　者：方星星[1] 王维[2] 李素梅[1] 

机构地区：[1]安徽医科大学附属省立医院内分泌科,中国合肥230001 [2]安徽医科大学病原生物学教研室,中国合肥230032

出　　处：《国际老年医学杂志》2012年第4期181-184,共4页International Journal of Geriatrics

摘　　要：目前认为CD4＋T细胞调节功能的失衡是1型糖尿病（type 1 diabetes mellitus T1DM）发病的中心环节，Th1亚群主要介导致病性的免疫反应，而Th2亚群主要介导保护性的免疫反应。辅助性T细胞的缺失是免疫耐受破坏的基础，IL-17可加重糖尿病病情。T1DM个体感染血吸虫后Th1／Th2免疫偏移，可减轻胰岛细胞损害程度以及降低血糖水平，对TIDM的防治提供了新的思路。The regulatory function imbalance of CD4 ＋ T cells is considered as the central link in oneset type 1 diabetes （T1DM）. Thl subsets mainly mediate pathogenic immune response and Th2 subsets mainly mediate protective immune response. The absence of regulatory T cell is the basis of immune tolerance damage. IL - 17 may increases the diabetic condition. The Thl/Th2 im- mune deviation after T1DM individuals are infected by schistosomes can reduce the extent of islet cell damage and decrease blood glu- cose levels, which provides a new way of prevention and treatment of T1DM.

关 键 词：1型糖尿病 血吸虫 T细胞调节 TH1 TH2 

分 类 号：R587.1[医药卫生—内分泌]