阿昔洛韦/赖氨酸壳聚糖纳米粒的理化性质考察  

Evaluation of Physicochemical Properties for Acyclovir/Lysine-chitosan Nanoparticles in Vitro

作　　者：李佳琳[1] 孟萍[1] 刘春年[1] 颜承云[1] 

机构地区：[1]佳木斯大学药学院,黑龙江佳木斯154007

出　　处：《长春师范大学学报（人文社会科学版）》2012年第6期24-26,共3页Journal of Changchun Teachers Coliege

基　　金：黑龙江省自然科学基金项目(D201054)

摘　　要：考察阿昔洛韦/赖氨酸壳聚糖纳米粒的理化性质。利用激光粒度分析仪、透射电镜、扫描电镜、高效液相色谱仪等测定载药纳米粒的形态、粒径、包封率和载药量,并考察载药纳米粒的体外释放行为。考察结果,微球呈类圆形,具有明显的核壳;载药的粒子平均粒径大小为107.96 nm;包封率为(61.24±0.68)%;载药量为(15.36±0.65)%;体外释放符合Higuchi模型。结论:阿昔洛韦/赖氨酸壳聚糖纳米粒理化性能具有良好的稳定性,符合实验设计要求。Objective： To investigate physical and chemical properties of nanoparticles. Methods： Using laser particle size analyzer, transmission electron microscope, scanning electron microscope and high performance liquid chromatograph to determin the form, particle size, entrapment efficiency and drug loading of drug-loaded nanoparticles, and investigate its release behavior. Results： The nanoparticles was spherical with obvious nuclear shell, the nanoparticles had average diameter of 107.96nm, entrapment efficiency of （61.2 ± 0.68）%, drug loading capacity of （15.36 ±0.65）%, and the in virto release effect was true of Higuchi equation.Conclusion： The particle stability of acyclovir lysine-chitosan nanoparticles was tranquilization.

关 键 词：三草酸合铁(Ⅲ)酸钾 合成 优化 

分 类 号：R284[医药卫生—中药学]