The role of endothelial progenitor cells in restenosis and stent thrombosis after percutaneous coronary intervention  

作　　者：吴良范 雷寒 常静 

机构地区：[1]Cardiology Department,First Affiliated Hospital of Chongqing Medical University

出　　处：《South China Journal of Cardiology》2012年第2期115-126,共12页岭南心血管病杂志（英文版）

摘　　要：Background After percutaneous coronary intervention （PCI）, some patients may suffer from restenosis and stent thrombosis. Many studies suggest that endothelial progenitor cell （EPC） has an important role in preventing restenosis and stent thrombosis. A novel stent which can attract EPC has been designed to provide a better outcome for these problems. Method The data of the present review was obtained by searching PUBMED and other databases （ 1994-2011 ） using the key terms of ＂endothelial progenitor cell＂, ＂reendothelialization＂, ＂restenosis＂, ＂stent thrombosis＂, and ＂percntaneous coronary intervention＂. Result Rapid reendothelialization is essential in preventing restenosis and stent thrombosis. EPC can differentiate into endothelial cell and accelerate the reendothelialization. After numerous preclinical and clinical researches, the correlation between circulating EPCs to restenosis still remains poorly understood. However, many studies have shown the important role of EPC in diminishing the risk of thrombosis following stent implantation. Some pharmacological agents have been reported can increase the number and/or functions of EPC. Recently, CD34＋ antibody coated stent has been developed to attract EPC to the healing endothelium, and has showed favorable results. Conclusion EPC has important role in rapid reendothelialization after vascular injury. EPC can prevent stent thrombosis after PCI, however the effects of EPC in preventing restenosis need further investigations. The capturing CD34＋ stent is safe and significantly decreases stent thrombosis.Background After percutaneous coronary intervention （PCI）, some patients may suffer from restenosis and stent thrombosis. Many studies suggest that endothelial progenitor cell （EPC） has an important role in preventing restenosis and stent thrombosis. A novel stent which can attract EPC has been designed to provide a better outcome for these problems. Method The data of the present review was obtained by searching PUBMED and other databases （ 1994-2011 ） using the key terms of ＂endothelial progenitor cell＂, ＂reendothelialization＂, ＂restenosis＂, ＂stent thrombosis＂, and ＂percntaneous coronary intervention＂. Result Rapid reendothelialization is essential in preventing restenosis and stent thrombosis. EPC can differentiate into endothelial cell and accelerate the reendothelialization. After numerous preclinical and clinical researches, the correlation between circulating EPCs to restenosis still remains poorly understood. However, many studies have shown the important role of EPC in diminishing the risk of thrombosis following stent implantation. Some pharmacological agents have been reported can increase the number and/or functions of EPC. Recently, CD34＋ antibody coated stent has been developed to attract EPC to the healing endothelium, and has showed favorable results. Conclusion EPC has important role in rapid reendothelialization after vascular injury. EPC can prevent stent thrombosis after PCI, however the effects of EPC in preventing restenosis need further investigations. The capturing CD34＋ stent is safe and significantly decreases stent thrombosis.

关 键 词：endothelial progenitor cell REENDOTHELIALIZATION RESTENOSIS stent thrombosis PCI 

分 类 号：R543[医药卫生—心血管疾病]