生物医学诊疗用磁性微纳材料  

Biological Magnetic Micro/Nano Materials for Theranostics

作　　者：蔡晓巍[1,2] 阮晓博[1,2] 房坤[1,2] 杨芳[1,2] 顾宁[1,2] 

机构地区：[1]东南大学生物电子学国家重点实验室,江苏南京210009 [2]江苏省生物材料与器件重点实验室,江苏南京210096

出　　处：《中国材料进展》2012年第6期1-6,55,共7页Materials China

基　　金：国家自然科学基金资助项目(Nos:50872021;31000453)

摘　　要：磁性微气泡是由包膜微气泡和磁性纳米粒子组成的微纳复合结构,由于其具有超声对比剂和核磁共振对比剂的双重特性,已被应用于双模造影领域。声致穿孔现象(Sonoporation)使得磁性微气泡能介导多种生物学效应,使其在药物输运和基因转染等方面有潜在的应用价值,而磁性微气泡与各种生物分子(抗体、肿瘤标记物等)的偶联,又扩展了磁性微气泡的应用领域,可用于分子影像诊断和靶向治疗肿瘤等方面,可以说磁性微气泡是新一代的生物医学诊疗用磁性微纳材料。总结了磁性微气泡的制备方法,磁性纳米颗粒与微气泡的结合方式,磁性微气泡的功能扩展,以及磁性微气泡在生物医学诊疗领域的实验研究,最后对磁性微气泡在未来的发展方向提出了一些构想,展望了磁性微气泡在诊疗学上广阔的应用前景。Magnetic microbubble is a micro/nann binary structure composed of encapsulated microbubble and magnetic nanoparticles. Magnetic microbubbles have been used in dual-mode imaging for the double properties of ultrasound ima- ging and magnetic resonance imaging. Sonoporation makes magnetic microbubbles to conduct enormous bio-effects, which have great potential application value in drug delivery and gene transfection. The coupling of magnetic microbubbles to oth- er biomolecules （antibodies, tumor markers and so on） expands the applications of magnetic microbubbles, such as mo- lecular imaging and targeted tumor therapy. So it is proposed that magnetic microbubbles can be potentially applied as a new generation of biological magnetic micro/nano materials for theranostics. This review summarizes the methods to gener- ate magnetic microbubbles, the forms of nanoparticles binding to microbubbles, the functional expanding of magnetic mi- crobubbles and the experimental studies of magnetic microbubbles for biomedical theranostics. In the end, this review rai- ses some ideas of the future development for magnetic microbubbles, and looks forward to the extensive prospects of mag- netic microbubbles for theranostics.

关 键 词：磁性微气泡 诊疗学 微纳复合结构 

分 类 号：O631[理学—高分子化学]