小分子硼酸肽的自组装  

Self-Assembly of Oligo-Borono-Peptides

作　　者：陈昌盛[1] 李仕颖[1] 王俊[1] 张先正[1] 卓仁禧[1] 

机构地区：[1]武汉大学化学与分子科学学院生物医用高分子材料教育部重点实验室,湖北武汉430072

出　　处：《中国材料进展》2012年第6期49-54,共6页Materials China

基　　金：科技部973计划项目(2011CB606202);基金委面上项目(20974083);中央高校基本科研业务费专项资金资助项目(201120302020004)

摘　　要：利用FMOC化学固相多肽合成法合成了3种含精氨酸的小分子硼酸肽(标记为BPs(1-3))。在生理pH下,含阳离子的硼酸肽可自组装形成有序超分子纳米组装体。二羟基酚染料茜素红与硼酸肽可特异性结合形成五元环硼酸酯,伴随荧光和颜色的显著变化,可进一步调控硼酸肽的自组装行为。通过扫描电镜研究茜素红调控前后硼酸肽的自组装形态,并用红外光谱和圆二色谱研究其自组装机理。结果表明,3种含精氨酸硼酸肽在生理pH下可自组装形成不同的超分子纳米组装体。通过茜素红的调控,茜素红/硼酸肽化合物,可自组装形成更有序,更精致的超分子聚集体。Three arginine-containing oligo-borono-peptides （BPs （1-3）） were synthesized by employing a standard FMOC chemistry SPPS. BPs（1-3） could spontaneously self-assemble into supramolecular architectures at a physiological environment. With recognition between BPs and alizarin red S （ARS） , the five-membered ring borate esters （ARS/BPs） could be formed with dramatic changes in fluorescent feature and visible color. These self-assembled supramolecular archi- tectures were observed by scanning electron microscope （SEM） and their self-assembly mechanisms were explored by Fou- rier Transform Infrared Spectroscopy （FT-IR） and Circular Dichroism （CD）. It was found that BPs were capable of self- assembling into well-ordered supramolecular architectures, and after recognition of ARS, ARS/BPs could further self-as- semble into more ordered and sophisticated supramolecular architectures.

关 键 词：硼酸肽 自组装 超分子聚集体 纳米材料 

分 类 号：R318.08[医药卫生—生物医学工程]