Antimicrobial Aromatic Polyketides from Gorgonian- Associated Fungus, Penicillium commune 518  

作　　者：王俊锋 刘培培 王义 王慧 李静 庄以彬 朱伟明 

机构地区：[1]Key Laboratory of Marine Drugs,Chinese Ministry of Education,School of Medicine and Pharmacy,Ocean University of China,Qingdao,Shandong 266003,China

出　　处：《Chinese Journal of Chemistry》2012年第6期1236-1242,共7页中国化学（英文版）

摘　　要：Seven new aromatic polyketides, communols A-G （1-7）, were isolated and identified from the fermentation broth of Penicillium commune 518, a marine-derived fungus associated with the Gorgonian, Muricella abnormalis. The new structures of 1-7 were determined by spectroscopic analysis and X-ray single crystal diffraction. Among them, communol D （4） was the first example of a naturally occurring aromatic polyketide with a sulfoxide group from marine thngi. Compounds 1, 6, and 7 all showed moderate antimicrobial activities against Escherichia coli and Enterobacter aerogenes with MIC values of 4.1/16.4, 6.4/25.8, and 23.8/23.8μmoloL^-1, respectively.Seven new aromatic polyketides, communols A-G （1-7）, were isolated and identified from the fermentation broth of Penicillium commune 518, a marine-derived fungus associated with the Gorgonian, Muricella abnormalis. The new structures of 1-7 were determined by spectroscopic analysis and X-ray single crystal diffraction. Among them, communol D （4） was the first example of a naturally occurring aromatic polyketide with a sulfoxide group from marine thngi. Compounds 1, 6, and 7 all showed moderate antimicrobial activities against Escherichia coli and Enterobacter aerogenes with MIC values of 4.1/16.4, 6.4/25.8, and 23.8/23.8μmoloL^-1, respectively.

关 键 词：Penicillium commune marine-derived fungus GORGONIAN Muricella abnormalis aromatic polyketide antimicrobial acti＇ ＇ity 

分 类 号：Q81[生物学—生物工程] TQ342.72[化学工程—化纤工业]