Chemical Components of Dendrobium chrysotoxum  

作　　者：胡江苗 范卫卫 董发武 缪泽鸿 周俊 

机构地区：[1]State Key Laboratory of Phytochemistry and Plant Resource in West China,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming,Yunnan 650204,China [2]Graduate School of Chinese Academy of Sciences,Beijing 100039,China [3]Division of Anti-Tumor Pharmacology,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China

出　　处：《Chinese Journal of Chemistry》2012年第6期1327-1330,共4页中国化学（英文版）

摘　　要：Two new phenanthrenes, named chrysotoxols A and B （1, 2） and 24 known compounds were isolated from the stems of the accession species in 2010 Chinese Pharmacopoeia of＂Shihu＂, Dendrobium chrysotoxum. All structures were elucidated by spectroscopic （NMR, MS, UV and IR） methods and the comparison with reported data in the literatures. Compound 2 and six known phenols were assessed for cytotoxic activity against two human tumor cell lines （A549 and HL-60）. The results indicated that erianin may have cytotoxic activity and the other six compounds lost activity at the concentration down to 10^-5 mol·L^-1.Two new phenanthrenes, named chrysotoxols A and B （1, 2） and 24 known compounds were isolated from the stems of the accession species in 2010 Chinese Pharmacopoeia of＂Shihu＂, Dendrobium chrysotoxum. All structures were elucidated by spectroscopic （NMR, MS, UV and IR） methods and the comparison with reported data in the literatures. Compound 2 and six known phenols were assessed for cytotoxic activity against two human tumor cell lines （A549 and HL-60）. The results indicated that erianin may have cytotoxic activity and the other six compounds lost activity at the concentration down to 10^-5 mol·L^-1.

关 键 词：ORCHIDACEAE Dendrobium chrysotoxum chrysotoxol PHENANTHRENE cytotoxic activity 

分 类 号：Q255[生物学—细胞生物学] S567.239[农业科学—中草药栽培]