B族维生素对冠心病患者血栓素B_2和6-酮-前列腺素F_(1a)的影响  

Influence of B-vitmins on TXB_2 and 6-K-PGF_(1a) in patients with coronary heart disease

作　　者：袁宇[1] 赵国安[1] 谷兆侠[2] 王卫民[1] 

机构地区：[1]新乡医学院一附院,河南卫辉453100 [2]新乡医学院生物化学教研室,河南新乡453003

出　　处：《新乡医学院学报》2000年第2期90-91,共2页Journal of Xinxiang Medical University

基　　金：河南省自然科学基金!资助项目 (96 12 0 0 6 11)

摘　　要：目的　了解B族维生素对冠心病患者血栓素B2 (TXB2 )、6 -酮 -前列腺素 (6 -K -PGF1a)的影响。方法　对 2 7例经冠状动脉造影证实的冠心病患者应用叶酸、维生素B6治疗 2wk ,采用放射免疫法测定治疗前后血浆中TXB2 、6 -K -PGF1a水平。结果　冠心病患者治疗后血浆TXB2 无明显改变 ,6 -K -PGF1a有明显升高 (P <0 .0 5 )。结论　应用B族维生素可提高 6 -K -PGF1a水平 ,改善TXB2 / 6 -K -PGF1a平衡 ,对防治冠心病具有一定价值。Objective To study the influence of B-vitmins on TXB 2 and 6-K-PGF 1a in patients with coronary heart disease(CHD). Methods Radioimmunoassay were used to measure the levels of TXB 2 and 6-K-PGF 1a in serum of patients with CHD undergone coronary angiography before and after of using folic acid and vitmin B 6 two weeks. Results The levels of TXB 2 were unchanged after two weeks dosing with B-vitmins,but significant increasing in 6-K-PGF 1a (P<0.05). Conclusions Application of B-vitmins will increase the level of 6-k-PGF 1a and improve the ratio of TXB 2 to 6-K-PGF 1a and confers some degree therapeutic and preventive value for CHD.

关 键 词：B族维生素 血栓素B2 冠心病 6-K-PGF1A 治疗 

分 类 号：R541.405[医药卫生—心血管疾病]