气温突变对高血压大鼠心梗发病及心肌损害的影响  

The Affect of Incidence of Myocardial Infarction and Myocardial Damage in Hypertensive Rats Induced by Sudden Rising and Dropping of Temperature

作　　者：罗颂明[1] 郭霞珍[1] 刘晓燕[1] 

机构地区：[1]北京中医药大学基础医学院,北京100029

出　　处：《现代生物医学进展》2012年第17期3224-3227,共4页Progress in Modern Biomedicine

基　　金：北京中医药大学自主选题资助项目(JYBZZ-JS020)

摘　　要：目的:探索气温突变对高血压大鼠心梗发病及心肌损害的影响。方法:给予肾动脉半结扎大鼠一次维生素D370 U/kg体重腹腔注射,22℃环境下饲以高脂饲料。10周后随机分为S、J和D三组,S组予以30分钟内升温至40℃处理,J组予以30分钟内降温至4℃的处理,D组为对照组。结果:S组大鼠急性心梗发病率为59.09%,J组大鼠发病率为26.32%,D组发病率为28.57%,S组大鼠以及J组大鼠血清肌钙蛋白、肌酸激酶、谷草转氨酶、肌酸激酶同工酶、乳酸脱氢酶含量(P<0.05)均明显高于D组大鼠,S组与D组大鼠肌钙蛋白等含量(P>0.1)无显著差异。结论:气温骤升、骤降均能加重造成心肌损害,但夏季气温骤升所造成的急性心梗发病率高于气温的骤降。Objective： To explore the affect of incidence of myocardial infarction and myocardial damage in hypertensive rats induced by sudden rising and dropping of temperature.Methods： Renal artery half ligated rats were treated with one intramuscular intraperitoneal injection of vitamin D3（7＊105U/kg） followed by high cholesterol diet in 22℃.After 10 weeks,divided all rats into random S,J,D groups.The S group is induced by rising to 40℃ in 30 minutes,the J group is induced by dropping to 4℃ in 30 minutes,and the D group is without induced.Results： The incidence of the S group is 59.09%,the incidence of the J group is 26.32%,and the D group is 28.57%.The content of Troponin,Creatine Kinase,creatine Kinase-MB,Aspartate aminotransferase,Lactate dehydrogenase in the S group and the incidence of the J group is higher than in the D group（P〈0.05）.and the content had no significant differences between the S group and the J group（P〈0.1）.Conclusions： The rising and dropping of temperature can create myocardial damage,and the rising of temperature can make more pathogenesis than the dropping of temperature.

关 键 词：急性心肌梗塞 心肌损害 大鼠 

分 类 号：S858.28[农业科学—临床兽医学] R541.4[农业科学—兽医学]