IFN-α治疗慢性乙型肝炎抗病毒疗效与血清IL-6变化的关系  

Study on the Relation between Changes of IL-6 in Serum in Patients with Chronic Hepatitis B and Action of Treatment with IFN-α

作　　者：何生松[1] 李淑莉[1] 熊莉娟[1] 刘薇[1] 曾令兰[1] 

机构地区：[1]同济医科大学附属协和医院,武汉430022

出　　处：《中西医结合肝病杂志》2000年第2期5-6,共2页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

基　　金：教育部回国人员科研启动基金;深圳科兴公司资助课题

摘　　要：目的:观察慢性乙型肝炎患者经α-干扰素(IFN-α)抗病毒治疗前后血清白细胞介素-6(IL-6)水平的变化与乙肝病毒消长之间的关系。方法:收集治疗前后血清标本—20C保存,通过ELISA法同步检测并与正常人做对照。结果:治疗前病人组血清中IL-6水平均较正常组高,尤其IFN-α治疗有效应答组增高明显。经IFN-α治疗的有效应答组IL-6水平较治疗前明显下降。结论:IFN-α除本身有抑制病毒复制外,通过免疫调节对病毒复制影响也具有重要作用。Aim: To investigate the relationship between the changes of interleukin-6 (IL-6) in serum from patients (25) with chronic hepatitis B (CHB) and antiviral action of IFN-α. Methods: Using ELISA for detection of IL-6 level change in serum of patients with CHB before and after IFN-α treatment. Results: Our date showed that the level of IL-6 in patients increased significantly as compared with normal subjects (P<0. 01), but the level in patients (10) with response to IFN-α treatment was significantly higher than that in nonresponse (15) (P<0. 01) , the IL-6 level after IFN-αtreatment was significantly lower than that before in response patients (P<0. 05). Conclusion: The results suggested that the immunoregulation of IFN-aaaaaaaa can play an important role in process of inhibiting HBV replication.

关 键 词：白细胞介素-6 Α-干扰素 乙型肝炎 治疗 

分 类 号：R512.6[医药卫生—内科学]