预防型抗氟剂(I型-1)急性毒性和致突变性研究  

Experimental study on the acute toxicity and mutagenesis of a preventive anti fluoride(I-1)

作　　者：张海谋[1] 刘克俭[1] 鲁翠荣[1] 穆雅笙[1] 陈荣安[1] 

机构地区：[1]同济医科大学职业医学研究所,湖北武汉430030

出　　处：《中国工业医学杂志》2000年第2期73-75,共3页Chinese Journal of Industrial Medicine

基　　金：国家"九五"科技攻关项目资助!(969060402)

摘　　要：目的　探讨预防型抗氟剂 (I型 1)的急性毒性和致突变效应。方法　小鼠灌胃 ,计算LD5 0 ;小鼠骨髓细胞微核试验 ;小鼠精子畸形试验。结果　预防型抗氟剂 (I型 1)LD5 0 为 1814mg/kg ;染毒组PCE微核率与阴性对照组无显著差别 ;高剂量组精子畸形率显著高于阴性对照组。结论　预防型抗氟剂 (I型 1)属低毒类物质 ,对小鼠骨髓细胞染色体无损伤效应 ,高剂量对生殖细胞可能产生影响。Objective To research the acute toxicity and mutagenesis of a preventive anti fluoride agent(I 1).Method Calculate the LD 50 P.O.of preventive anti fluorid(I 1)in mice,make the micronucleus test of mices marrow cell and deformity test of mices sperm.Result LD 50 of preventive anti fluorid(I 1)P.O.was 1 814 mg/kg,there was no significant difference in micronucleus rate between preventive anti fluorid(I 1) group and control group,but the deformity rate of sperm in highdose preventive anti fluorid(I 1) group was significantly higher than that of control group.Conclusions preventive anti fluorid(I 1)belong to a low toxicity compound,it wasnt harmful to chromosome of mices marrow cells,but reproductive cell might be affected by high dose preventive anti fluorid(I 1).

关 键 词：预防型抗氟剂 急性毒性试验 致突变试验 

分 类 号：R965.3[医药卫生—药理学] R979.3[医药卫生—药学]