酮基膦酸酯类化合物的合成  

Synthesis of β-ketophosphonates

作　　者：贾鹏飞[1] 王娟[1] 刘占荣[1] 姚清国[1] 

机构地区：[1]石家庄学院化工学院,河北石家庄050035

出　　处：《河北师范大学学报（自然科学版）》2012年第4期395-398,共4页Journal of Hebei Normal University：Natural Science

基　　金：石家庄市科学技术研究与发展计划(101071401)

摘　　要：探讨了几种酮基膦酸酯类化合物合成的新方法.以膦酰基乙酸酯为起始原料,先后经过酰化、脱羧和纯化得到酮基膦酸酯类化合物.通过优化实验条件筛选出最佳反应条件.对所合成化合物进行了31PNMR,1HNMR,13CNMR表征.该合成方法原料易得、操作简便、成本低廉,具有较高的工业价值.To investigate a novel synthetic method of some fl-ketophosphonates, ehtyl phosphonocarboxylate was used as the starting material to synthesize target compound through acylation, decarboxylation and purification. Technological parameters were optimized to screen the best conditions. The target compounds were identified with 3tPNMR,1HNMR and 13CNMR. The synthetic method has the advantages of available raw material, simple operation, lower cost and higher industrial value.

关 键 词：膦酰基乙酸酯 卤代苯 酰氯 合成 

分 类 号：O621.3[理学—有机化学]