心源性猝死病人心肌SOCS-1和C-JUN表达及法医学意义  

EXPRESSIONS OF SOCS-1 AND C-JUN IN MYOCARDIUM OF PATIENTS WITH SUDDEN CARDIAC DEATH AND THEIR SIGNIFICANCE IN FORENSIC MEDICINE

作　　者：刘志峰[1] 杨彦华[1] 董明霞[2] 卫红军[1] 张七一[3] 于建宪[1] 

机构地区：[1]青岛大学医学院附属青岛市市立医院病理科,山东青岛266011 [2]青岛市黄岛区中医院病理科 [3]青岛市市立医院心内科

出　　处：《齐鲁医学杂志》2012年第3期258-260,共3页Medical Journal of Qilu

基　　金：青岛市科技发展计划立项项目(05-2-NS-43)

摘　　要：目的探讨心源性猝死(SCD)病人细胞因子信号转导抑制分子-1(SOCS-1)和原癌基因蛋白(C-JUN)的表达及法医学意义。方法收集SCD尸检病理标本43例,其中冠心病猝死23例,肺动脉栓塞猝死12例,病毒性心肌炎猝死5例,扩张型心肌病猝死3例;选择因交通事故、外伤等所致死亡者标本10例为对照组。应用免疫组织化学方法检测两组心肌细胞中SOCS-1和C-JUN蛋白的表达。结果 SCD组心肌细胞中SOCS-1和C-JUN表达显著高于对照组(F=11.94、56.68,q=4.815～20.669,P<0.01)。SCD组心肌细胞中SOCS-1与C-JUN表达呈正相关(r=0.316,P<0.01)。结论 SCD病人心肌细胞内SOCS-1和C-JUN基因蛋白表达可能参与了SCD的发病,可作为法医鉴定SCD的重要指标。Objective To investigate the expressions of suppressors of cytokine signaling 1 （SOCS-1） and C-JUN in my ocardium of patients died of cardiac arrest （CA） and their significance in forensic medicine. Methods Forty-three myocardial au topsy specimens from patients died of CA were collected. Of which, 23 died of coronary heart disease, 12 of pulmonary embolism, five of viral myocarditis, and three of dilated cardiomyopathy; 10 cases died of traffic accident or trauma were served as controls. The expressions of myocardial SOCS-1 and C-JUN proteins were detected immunohistochemically. Results The expressions of SOCS-1 and C-JUN in myocardial cells of the patients died of CA were higher than that in the control （F= 11. 94,56. 68; q= 4. 815--20. 669;P〈0.01）. There was a positive correlation between myocardial SOCS-1 and C-JUN in CA patients （r= 0. 316, P〈0.01）. Conclusion The expressions of myocardial SOCS-1 and C JUN in patients died of cardiac arrest are likely to be＇in volved in the pathogenesis of this condition,which can be used as important parameters in medicolegal investigation.

关 键 词：猝死 心脏 细胞因子信号转导蛋白抑制因子 原癌基因蛋白质C-JUN 法医学 

分 类 号：R892[医药卫生—法医学]