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作 者:黄义昆[1] 夏涛[1] 秦荣新[1] 刘百义[1]
机构地区:[1]广西医科大学第五附属医院,广西柳州545006
出 处:《中国药师》2012年第6期872-874,共3页China Pharmacist
基 金:广西柳州市科技攻关项目(编号:20020231)
摘 要:目的:探讨不同剂量精氨酸(Arg)强化的肠外营养(TPN)对胃肠癌患者术后免疫功能的影响。方法:选择90例胃肠癌患者,术后分别给予肠外营养支持,随机分为对照组(常规TPN,30例),试验Ⅰ组(TPN+Arg 15 g,30例)和试验Ⅱ组(TPN+Arg 30 g,30例),分析术前术后不同时期白蛋白、总蛋白、C3、C4、CD4+、CD8+、CD4+/CD8+等免疫功能指标变化。结果:与对照组相比,Arg强化的TPN试验组患者免疫功能在术后第4天均有明显改善(P<0.05),随着精氨酸剂量的增加,总蛋白、CD4+、CD8+、CD4+/CD8+等指标改善更为显著(P<0.01)。结论:精氨酸强化的TPN能提高胃肠癌患者术后免疫功能,添加精氨酸30 g优于15 g。Objective: To evaluate the effects of arginine-enriched TPN on postoperative immune function in the patients with gas- trointestinal tumors. Method: 90 cases with gastrointestinal tumor operation were randomly divided into three groups: 30 eases in the control group with routine TPN, 30 cases in the test- I group with TPN + 15g arginine and 30 cases in the test- II group with TPN + 30 g arginine. The immune function ( ALB and TB, C3 , C4, CD4 + , CD8 + and CD4 + /CD8 + ) was detected preoperatively and postopera- tively at different time points. Result: The immune function was improved in the arginine-enriehed groups as compared with that in the control group on the 4th day after the operation ( P 〈 0.05 ). With the amount increase of arginine, the immune function was enhanced significantly. Conclusion: Arginine-enriched TPN can improve the immune function in the patients with gastrointestinal tumors, and 30 g L-arginine is better than 15 g one.
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