HIV/AIDS患者外周血EBV-DNA检测结果分析  

Results of detection of Epstein-Barr virus DNA in peripheral blood of HIV/AIDS patients

作　　者：吴驰[1] 赖文杰[1] 陈建波[1] 刘厚明[1] 肖颜玉[1] 叶飞娣[1] 单万水[1] 

机构地区：[1]深圳市第三人民医院检验科,深圳518020

出　　处：《中国热带医学》2012年第5期609-611,共3页China Tropical Medicine

摘　　要：目的了解深圳地区人免疫缺陷病毒(HIV)阳性患者和艾滋病(AIDS)患者外周血中EB病毒DNA的检出情况。方法收集257例HIV/AIDS患者外周血标本,采用实时荧光定量PCR技术检测EB病毒DNA水平。比较不同年龄、性别、门诊及住院HIV/AIDS患者的EBV-DNA阳性率并进行统计学分析。结果 HIV/AIDS患者EBV-DNA总检出率为32.30%(83/257),住院AIDS患者检出率为43.96%(40/91)明显高于门诊HIV/AIDS患者检出率(25.90%,43/166)。结论 HIV/AIDS患者外周血中EBV-DNA检出率较高,EBV-DNA阳性检出率随着HIV/AIDS患者病情的加重而增加。Objective To investigate the incidence of Epstein-Barr virus in HIV/AIDS patients from Shenzhen region.Methods The peripheral blood samples of 257 HIV/AIDS cases in Shenzhen Municipal Third People＇s Hospital from October 2010 to April 2011 were collected and the level of peripheral blood EBV DNA was determined by using fluorescent quantitative PCR,and the infection rate of EBV in HIV-infected patients was analyzed.Results A total of 83 patients（32.30%）carried Epstein-Barr virus.The detection rate of of Epslein rirus in AIDS inpatients was 43.96%,significantly higher than the outpatients（25.90%）.Conclusion The infection rate of Epstein virus in peripheral blood of HIV/AIDS cases is high and the positive rate of Epstein virus infection is getting higner alongside with the increase of severity of the disease.

关 键 词：HIV/AIDS EB病毒 荧光定量PCR 外周血 

分 类 号：R512.91[医药卫生—内科学]