瘦素受体基因Gln223Arg多态性与脑梗死和腹型肥胖关系  

Gln223Arg POLYMORPHISM IN LEPTIN RECEPTOR AND ITS ASSOCIATION WITH CEREBRAL INFARCTION AND ABDOMINAL OBESITY

作　　者：韩萌[1] 滕继军[1] 张文卿[2] 齐玉祥 张金玉[4] 姚如永[5] 

机构地区：[1]青岛大学医学院附属医院神经内科,山东青岛266003 [2]潍坊益都中心医院 [3]浙江台州中心医院 [4]青岛大学医学院生物化学与分子生物学教研室 [5]青岛大学医学院附属医院中心实验室

出　　处：《青岛大学医学院学报》2012年第4期309-312,共4页Acta Academiae Medicinae Qingdao Universitatis

摘　　要：目的探讨瘦素受体基因Gln223Arg多态性与脑梗死和腹型肥胖的相关性。方法用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法,检测295例脑梗死病人和256例健康对照人群(对照组)的瘦素受体基因Gln223Arg多态性;根据腹围标准将两组均分成腹型肥胖组和非腹型肥胖组,分析瘦素受体基因Gln223Arg多态性与脑梗死及腹型肥胖的关系。结果脑梗死和对照组比较,基因型分布差异有显著性(χ2=31.779,P<0.01),等位基因差异亦有显著性(OR=1.956,95%CI1.527～2.506,χ2=28.51,P<0.01)。腹型肥胖与非腹型肥胖组基因型分布比较差异无统计学意义(χ2=4.475,P>0.05)。结论瘦素受体基因Gln223Arg多态性可能与脑梗死有关,G等位基因可能增加脑梗死发病风险,而与腹型肥胖无关。Objective To explore the Gln223Arg polymorphism in leptin receptor （LEPR） and its correlation with cere- bral infarction （CI） and abdominal obesity （AO）. Methods The Gln223Arg polymorphism was studied by polymerase chain re- action and restrictive fragment length polymorphism （PCR-RFLP） in 295 patients with CI and 256 healthy controls. They were di vided into AO group and non-AO group according to international standard of abdomen circumference. The correlation of Gln223Arg polymorphism with CI and AO was analyzed. Results The difference of distribution of genotype of Gln223Arg poly- morphism in LEPR between CI and controls was significant （χ^2= 31. 779, P 〈0. 01 ）, so did as allele （OR = 1. 956,95 % CI 1. 527-2. 506,χ^2= 28.51, P〈0.01）. The difference of genotype distribution between AO and non-AO group was not statistically significant （χ^2=4. 475,P〉0.05）. Conclusion Gln223Arg polyraorphism in LEPR is possibly associated with cerebral infarc- tion and not with abdominal obesity, and G allele is likely to increase the risk of cerebral infarction.

关 键 词：瘦素受体 多态性 单核苷酸 脑梗塞 肥胖症 

分 类 号：R589.2[医药卫生—内分泌] R743.3[医药卫生—内科学]