姜黄素对小鼠胃肠蠕动的影响及其作用机制  

EFFECT OF CURCUMIN ON GASTROINTESTINAL PERISTALSIS IN MICE

作　　者：罗霜[1,2] 于小玲[1] 李红静[1] 

机构地区：[1]青岛大学医学院病理生理学教研室,山东青岛266021 [2]山东省菏泽医学专科学校

出　　处：《齐鲁医学杂志》2012年第5期430-431,共2页Medical Journal of Qilu

基　　金：山东省卫生厅计划项目(HW0234)

摘　　要：目的探讨姜黄素灌胃对小鼠胃肠运动的影响及其相关机制。方法将昆明种小鼠随机分为对照组、姜黄素组、阿托品组、姜黄素+阿托品组、L-精氨酸组与姜黄素+L-精氨酸组。墨汁灌胃法检测小鼠小肠推进率。结果姜黄素组小鼠与对照组比较小肠推进率无显著变化(P>0.05),阿托品组和L-精氨酸组小鼠小肠推进率显著下降,而姜黄素+阿托品组和姜黄素+L-精氨酸组小鼠的小肠推进率分别与阿托品组和L-精氨酸组比较有显著提高(F=9.50、21.31,t=3.93、10.51,P<0.01)。结论姜黄素并不影响正常小鼠的胃肠蠕动;姜黄素可明显对抗阿托品和L-精氨酸所致小鼠胃肠蠕动减弱;姜黄素可能通过激动M-胆碱受体和阻止NANC神经的抑制性神经递质NO的作用来促进胃肠蠕动。Objective To study the effect of curcumin on gastrointestinal peristalsis in mice and its correlative mecha- nism. Methods Kunnfing mice were randomized to six groups as： control group, atropine group, cureumin group, curcumin-- atropine group, L-arginine group and curcnmin＋ L-arginine group. The motional rate of small intestine was detected using ink lav- age method. Results Compared with the control group, the motility of small intestine of the mice in eurcumin group showed no significant difference （P：〉0.05） ; that in atropine group or in L arginine group was lowered; and that in curcumin＋atropin group or curcumin＋ L argininc group was stronger than that in atropine group or in L-arginine group, respectivly （F=9.50,21.31;t = 3.93,10.51 ;P〈0.01）. Conclusion Cnrcumin does not affect normal gastrointestinal motility of mice, which can significantly antagonize the weakness of gastrointestinal motility induced by atropine and L- arginine. Curcnmin promote the motility of gastroi- ntestine is probably by activating M-receptor and preventing nitric oxide pathway of rejecting neurotransmitter of NANC nerve.

关 键 词：姜黄素 阿托品 L精氨酸 一氧化氮 胃肠蠕动 

分 类 号：R332[医药卫生—人体生理学]