尿液的采集时间对尿汞测定结果的影响  

Influence of urine collection time on determination results of urinary mercury

作　　者：董博芳[1] 吴命君[1] 刘宏鹏[1] 

机构地区：[1]河北省石家庄市职业病防治院中心实验室,050031

出　　处：《职业与健康》2012年第11期1342-1343,1346,共3页Occupation and Health

摘　　要：目的更准确地掌握人体不同尿液采集时间尿汞含量的大小,以便为临床治疗汞中毒提供更可靠的数据。方法采集不同时间点的尿液,用WS/T97的方法测定尿肌酐,用原子荧光光谱法测定尿汞。结果同一患者3 d晨尿、随机尿液(每天3次)以及24 h尿液的尿汞肌酐校正平均值与T值(所有尿汞肌酐校正值的平均值)的差异分别为0.5%、0.8%、22.4%、22.4%、0.1%;不同患者晨尿与T24(24小时尿液的尿汞肌酐校正值)差异值在10%以内,而随机尿液与T24的差异值波动较大,从2.2%～196%,且无特定规律。结论 24 h尿液和晨尿的尿汞肌酐校正值最为稳定,住院患者最好留取24h尿液,而门诊患者应留取晨尿,随机尿液的尿汞肌酐校正值差异较大,不具有临床意义。[Objective]To accurately know the contents of urinary mercury with different urine collection time,provide the reliable data for clinical treatment of mercury poisoning.[Methods]The urine samples were collected at different time points,and the content of urinary creatinine and urinary mercury was respectively determined by method of WS/T97 and atomic fluorescence spectrometry.[Results]In same patient,the difference between the creatinine-corrected mean of urinary mercury of morning urine,random urine（three times a day）,24 h urine and T value（mean of all creatinine-corrected value of urinary mercury） was 0.5%,0.8%,22.4%,22.4% and 0.1%,respectively.In different patients,the difference between the creatinine-corrected mean of morning urine and T-24 value（creatinine-corrected value of 24 h urinary mercury） was within 10%.The difference between the corrected mean of random urine and T-24 value ranged from 2.2% to 196%,and there was no specific law.[Conclusion]The creatinine-corrected values of urinary mercury of 24 h urine and morning urine are the most stable.It is suggested to collect 24 h urine samples from inpatients and morning urine samples from outpatients.There are great differences in creatinine-corrected values of random urine samples,so it had no clinical value.

关 键 词：尿汞含量 采集时间 晨尿 24h尿液 随机尿液 

分 类 号：R446.12[医药卫生—诊断学]