PEG活化催化合成香豆素  

Polyethylene GlycolActivated Catalytic Synthesis of Coumarin

作　　者：肖如亭[1] 李乃 吴志东[1] 葛明 

机构地区：[1]天津理工学院化工系,天津300191

出　　处：《石油化工》2000年第5期356-357,391,共3页Petrochemical Technology

摘　　要：对以水杨醛和乙酸酐为原料合成香豆素的工艺进行了改进。采用以乙酸钙为催化剂、PEG为催化活化剂的工艺路线 ,提高了产物的收率。同时对催化剂和活化剂的用量及反应温度和反应时间的影响进行了研究 ,确定了最佳工艺条件 ,并提出PEG的活化催化作用主要是配位作用和对催化剂的增溶作用。反应物的质量比为水杨醛 /乙酸酐 /乙酸钙 /PEG =1 / 1 6/ 0 0 3 / 0 1 ,反应近终点时在 ( 2 1 4± 2 )℃再保温反应 0 5h ,香豆素收率可达 80 6%。The synthesis of coumarin from salicylaldehyde and acetic anhydride was improved with higher yield by using calcium acetate as catalyst and polyethylene glycol as catalytic activator.The influence of quantity of catalyst and activator,reaction temperature and reaction time on yield was studied and the optimum technological conditions were determined.Coordination and increase in solubility of the catalyst was proposed as the mechanism of activation of polyethylene glycol.The yield of coumarin can reach 806% when the ratio in weight of starting meterials is salicylaldehyde:acetic anhydride:calcium acetate:polyethylene glycol=1∶16∶003∶01,and the reaction is further kept for 05 h at (214±2) ℃ when the reaction is close to the end point.

关 键 词：香豆素 PEG 乙酸钙 活化 催化 合成香料 

分 类 号：TQ655[化学工程—精细化工] TQ253.1