儿童慢性消化系统疾病与食物不耐受的相关性研究及饮食调节后的疗效分析  

CORRELATION BETWEEN CHILDREN CHRONIC DIGESTIVE DISEASE AND THE FOOD INTOLERANCE AND CURATIVE EFFECT ANALYSIS OF ANTISECOSIS

作　　者：张洁[1] 吴永利[1] 郗瑞倩[1] 

机构地区：[1]河北省沧州市中心医院儿科,河北沧州061001

出　　处：《河北医科大学学报》2012年第7期776-779,共4页Journal of Hebei Medical University

摘　　要：目的探讨儿童慢性消化系统疾病与食物不耐受的相关性,并在饮食调节后进行疗效分析。方法采用酶联免疫吸附测定(enzyme linked immunosorbent assay,ELISA)法,检测114例消化系统疾病(包括慢性腹泻、厌食、腹痛、便秘、恶心呕吐、腹胀,并除外器质性疾病)患儿血清中食物特异性IgG抗体的浓度。将结果阳性的患儿随机分为试验组和对照组,2组患儿均口服药物治疗,当病情得到控制后均停药。与此同时试验组对检测出的不耐受食物进行饮食调节,对照组正常饮食,观察2组患儿病情改善情况。结果 114例慢性消化系统疾病患儿中,有104例食物特异性IgG升高,总阳性率为91.2%;在14种食物中对蛋清/蛋黄和牛奶的不耐受率最高,分别为84.6%、59.6%;治疗3个月后试验组治疗有效率96.2%,对照组治疗有效率38.5%。结论儿童慢性消化系统疾病与食物不耐受有密切相关性,通过检测血清中食物特异性IgG抗体,找出不耐受的食物,通过饮食调节,使病情得到明显改善。因此测定血清中食物特异性IgG抗体对治疗及预防这些疾病有重要的指导意义。Objective To study the correlation between children chronic digestive disease and the food intolerance, and evaluate the curative effect of antisecosis. Methods A total of 114 children with chronic digestive disease （ including chronic diarrhea, anorexia, abdominal pain, constipation, nausea vomiting, abdominal distension, and organic diseases were excluded ） were enrolled into the study, who were measured serum food - specific IgG antibodies by using enzyme linked immunosorbent assay （ELISA）. The positive cases were divided randomly into experimental group and the control group. Both were treated by oral therapy, and medication was discontinued after disease control. Meanwhile experimental group was given food adjustment according to the intolerant food, and control group kept a normal diet. The improvement of clinical symptoms in children of two groups were observed carefully. Results There were 104 cases of positive food - specific serum IgG in the 119 cases of chronic digestive diseases, the total positive rate was 91.2%. The positive rates of egg white/egg yolk and milk, which were higher than any other of the detection of 14 food items, were 84.6% and 59.6% respectively. The effective rate of treatment in the experimental group was 96.2%, and the control group was 38.5%. Conclusion The results showed that there was a correlation between children chronic digestive diseases and the food intolerance. Therefore, the detection of food - specific IgG antibodies had important directive significance for the diagnosis, treatment and prevention of these diseases.

关 键 词：消化系统疾病 食物不耐受 儿童 

分 类 号：R725.7[医药卫生—儿科]